1TV6

HIV-1 Reverse Transcriptase Complexed with CP-94,707

Summary for 1TV6

• Entry DOI: 10.2210/pdb1tv6/pdb
• Related: 3HVT
• Descriptor: reverse transcriptase p66 subunit, reverse transcriptase p51 subunit, 3-[4-(2-METHYL-IMIDAZO[4,5-C]PYRIDIN-1-YL)BENZYL]-3H-BENZOTHIAZOL-2-ONE (3 entities in total)
• Functional Keywords: transferase
• Biological source: Human immunodeficiency virus type 1 BH10; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 116260.51

Authors

Pata, J.D.,Stirtan, W.G.,Goldstein, S.W.,Steitz, T.A. (deposition date: 2004-06-28, release date: 2004-07-20, Last modification date: 2023-08-23)

• Primary citation: Pata, J.D.,Stirtan, W.G.,Goldstein, S.W.,Steitz, T.A.; Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant RTs resistant to other non-nucleoside inhibitors; Proc.Natl.Acad.Sci.USA, 101:10548-10553, 2004; PubMed: 15249669; DOI: 10.1073/pnas.0404151101

Experimental method

X-RAY DIFFRACTION (2.8 Å)