1TV6

HIV-1 Reverse Transcriptase Complexed with CP-94,707

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CP9 A 561

Chain	Residue
A	PRO95
A	TYR318
A	LEU100
A	VAL106
A	VAL108
A	TYR181
A	TYR188
A	LEU234
A	HIS235
A	PRO236

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	ZN_FING: CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047

Chain	Residue	Details
B	LYS223-THR240

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site_id	SWS_FT_FI2
Number of Residues	17
Details	ZN_FING: CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047

Chain	Residue	Details
B	ILE244-VAL261

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029

Chain	Residue	Details
B	ARG358

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cis/trans isomerization of proline peptide bond; by human PPIA/CYPA => ECO:0000250

Chain	Residue	Details
B	ASN54

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Cleavage; by viral protease => ECO:0000250

Chain	Residue	Details
B	GLY196
B	LEU210

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000255

Chain	Residue	Details
B	ASN265
A	LEU210

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site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Cleavage; by viral protease

Chain	Residue	Details
B	GLY273
B	GLY333

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site_id	SWS_FT_FI8
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000269|PubMed:2476069

Chain	Residue	Details
B	GLU432
A	GLY333

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site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034

Chain	Residue	Details
B	LYS220
B	GLN242

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site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034

Chain	Residue	Details
A	LYS220
A	GLN242

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