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3HVT

STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER

Replaces:  2HVTReplaces:  1HVT
Summary for 3HVT
Entry DOI10.2210/pdb3hvt/pdb
DescriptorHIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66), HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P51), 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE (3 entities in total)
Functional Keywordsnucleotidyltransferase
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
Total number of polymer chains2
Total formula weight114326.18
Authors
Steitz, T.A.,Smerdon, S.J.,Jaeger, J.,Wang, J.,Kohlstaedt, L.A.,Chirino, A.J.,Friedman, J.M.,Rice, P.A. (deposition date: 1994-07-25, release date: 1994-10-15, Last modification date: 2024-02-21)
Primary citationSmerdon, S.J.,Jager, J.,Wang, J.,Kohlstaedt, L.A.,Chirino, A.J.,Friedman, J.M.,Rice, P.A.,Steitz, T.A.
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
Proc.Natl.Acad.Sci.Usa, 91:3911-3915, 1994
Cited by
PubMed: 7513427
DOI: 10.1073/pnas.91.9.3911
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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