PDB: 37722 件ウェブページステータス検索Chemie searchBIRD

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6R99	Crystal Structure of Human CLN protein 5 (Ceroid Lipofuscinosis Neuronal Protein 5) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ceroid-lipofuscinosis neuronal protein 5, ... 著者 Luebben, A.V, Sheldrick, G.M. 登録日 2019-04-03 公開日 2020-04-22 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Cln5 represents a new type of cysteine-based S -depalmitoylase linked to neurodegeneration. Sci Adv, 8, 2022
6NZ5	YcjX-GDPCP 分子名称: GUANOSINE-5'-DIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, YcjX Stress Protein 著者 Lee, S, Tsai, J, Tsai, F.T, Sung, N, Lee, J, Chang, C. 登録日 2019-02-12 公開日 2019-09-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.233 Å) 主引用文献 Crystal Structure of the YcjX Stress Protein Reveals a Ras-Like GTP-Binding Protein. J.Mol.Biol., 431, 2019
6E0N	Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with GTP and Apcpp 分子名称: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Eaglesham, J.B, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Nieminen, E.A, King, D.S, Lee, A.S.Y, Mekalanos, J.J, Kranzusch, P.J. 登録日 2018-07-06 公開日 2019-02-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature, 567, 2019
6DZI	Cryo-EM Structure of Mycobacterium smegmatis 70S C(minus) ribosome 70S-MPY complex 分子名称: 16S rRNA, 23 S rRNA (3119-MER), 30S ribosomal protein S10, ... 著者 Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A. 登録日 2018-07-05 公開日 2018-09-26 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.46 Å) 主引用文献 Zinc depletion induces ribosome hibernation in mycobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6E0T	C-terminal domain of Fission Yeast OFD1 分子名称: Prolyl 3,4-dihydroxylase ofd1 著者 Bianchet, M.A, Amzel, L.M, Espenshade, P.J, Yeh, T. 登録日 2018-07-06 公開日 2019-09-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor. Structure, 19, 2011
6E20	Crystal structure of the Dario rerio galectin-1-L2 分子名称: Galectin, MAGNESIUM ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose 著者 Ghosh, A, Bianchet, M.A. 登録日 2018-07-10 公開日 2019-03-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the zebrafish galectin-1-L2 and model of its interaction with the infectious hematopoietic necrosis virus (IHNV) envelope glycoprotein. Glycobiology, 29, 2019
6EBE	Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. 分子名称: 4-hydroxy-3-nitro-5-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Singh, S, McKenna, R, Supuran, C.T, Nocentini, A, Lomelino, C, Lucarini, E, Bartolucci, G, Mannelli, L.D.C, Ghelardini, C, Gratteri, P. 登録日 2018-08-06 公開日 2018-11-28 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles. J. Med. Chem., 61, 2018
6NZN	Dimer-of-dimer amyloid fibril structure of glucagon 分子名称: Glucagon 著者 Gelenter, M.D, Smith, K.J, Liao, S.Y, Mandala, V.S, Dregni, A.J, Lamm, M.S, Tian, Y, Wei, X, Pochan, D.J, Tucker, T.J, Su, Y, Hong, M. 登録日 2019-02-14 公開日 2019-06-05 最終更新日 2024-05-15 実験手法 SOLID-STATE NMR 主引用文献 The peptide hormone glucagon forms amyloid fibrils with two coexisting beta-strand conformations. Nat.Struct.Mol.Biol., 26, 2019
8PM6	Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs 分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL 著者 Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. 登録日 2023-06-28 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.22 Å) 主引用文献 Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
6R4N	Crystal structure of S. cerevisia Niemann-Pick type C protein NPC2 with ergosterol bound 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ERGOSTEROL, ... 著者 Winkler, M.B.L, Kidmose, R.T, Pedersen, B.P. 登録日 2019-03-22 公開日 2019-09-25 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins. Cell, 179, 2019
6RA8	Horse spleen apoferritin under 2 kBar of argon 分子名称: ARGON, CADMIUM ION, Ferritin light chain, ... 著者 Prange, T, Carpentier, P, Colloc'h, N. 登録日 2019-04-05 公開日 2020-05-06 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Labelling protein crystals by argon at 2 kbar To be published
8PMD	Nucleotide-bound BSEP in nanodiscs 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, MAGNESIUM ION 著者 Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. 登録日 2023-06-28 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
8PMJ	Vanadate-trapped BSEP in nanodiscs 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, ... 著者 Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. 登録日 2023-06-28 公開日 2023-11-29 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
3IBU	The crystal structure of the human carbonic anhydrase II in complex with an aliphatic sulfamate inhibitor 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, CHLORIDE ION, Carbonic anhydrase 2, ... 著者 Alterio, V, De Simone, G. 登録日 2009-07-17 公開日 2009-09-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors J.Med.Chem., 52, 2009
6L1L	Apo-BacF structure from Bacillus subtillis 分子名称: Aminotransferase, PYRIDOXAL-5'-PHOSPHATE 著者 Balasubramanian, G, Deshmukh, A.A. 登録日 2019-09-29 公開日 2020-03-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into the catalytic mechanism of Bacillus subtilis BacF. Acta Crystallogr.,Sect.F, 76, 2020
6E3R	Structure of human DNA polymerase beta complexed with 8OA as the template base in a 1-nucleotide gapped DNA 分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2018-07-14 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases. J. Am. Chem. Soc., 141, 2019
6L4O	Crystal structure of API5-FGF2 complex 分子名称: Apoptosis inhibitor 5, Fibroblast growth factor 2 著者 Lee, B.I, Bong, S.M. 登録日 2019-10-18 公開日 2020-04-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Regulation of mRNA export through API5 and nuclear FGF2 interaction. Nucleic Acids Res., 48, 2020
6E3V	Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable TTP 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2018-07-15 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases. J. Am. Chem. Soc., 141, 2019
3IEO	The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example 分子名称: BENZOIC ACID, Carbonic anhydrase 2, MERCURY (II) ION, ... 著者 Temperini, C, Innocenti, A, Scozzafava, A, Parkkila, S, Supuran, C.T. 登録日 2009-07-23 公開日 2010-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors J.Med.Chem., 53, 2010
6E3W	Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable GTP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2018-07-15 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases. J. Am. Chem. Soc., 141, 2019
6EQU	X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor 分子名称: 4-[2-(2,4,6-triphenylpyridin-1-ium-1-yl)ethyl]benzenesulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Alterio, V, De Simone, G, Esposito, D. 登録日 2017-10-15 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor. J Enzyme Inhib Med Chem, 33, 2018
6ER5	X-ray structure of Trypanothione Reductase from Leishmania infantum in complex with 2-(diethylamino)ethyl 4-((3-(4-nitrophenyl)-3-oxopropyl)amino)benzoate 分子名称: 2-(diethylamino)ethyl 4-((3-(4-nitrophenyl)-3-oxopropyl)amino)benzoate, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... 著者 Ilari, A, Fiorillo, A. 登録日 2017-10-17 公開日 2018-10-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.37 Å) 主引用文献 Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening. Plos Negl Trop Dis, 12, 2018
6E3X	Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable ATP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*CP*GP*AP*CP*(A38) P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2018-07-15 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure of human DNA polymerase beta complexed with 8OA in the template base paired with incoming non-hydrolyzable ATP To Be Published
6E3Y	Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor 分子名称: Calcitonin gene-related peptide 1, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liang, Y.L, Khoshouei, M, Deganutti, G, Glukhova, A, Koole, C, Peat, T.S, Radjainia, M, Plitzko, J.M, Baumeister, W, Miller, L.J, Hay, D.L, Christopoulos, A, Reynolds, C.A, Wootten, D, Sexton, P.M. 登録日 2018-07-16 公開日 2018-09-19 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. Nature, 561, 2018
6KR3	Crystal structure of Dengue virus nonstructural protein NS5 (form 2) 分子名称: GLYCEROL, Genome polyprotein, IODIDE ION, ... 著者 Wu, J, Lu, G, Ye, H.Q, Gong, P. 登録日 2019-08-20 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.931 Å) 主引用文献 A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase. Plos Pathog., 16, 2020

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