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3IEO

The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example

Summary for 3IEO
Entry DOI10.2210/pdb3ieo/pdb
Related3F8E
DescriptorCarbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (6 entities in total)
Functional Keywordscarbonic anhydrase, antiepilectic, disease mutation, lyase, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P00918
Total number of polymer chains1
Total formula weight30128.07
Authors
Temperini, C.,Innocenti, A.,Scozzafava, A.,Parkkila, S.,Supuran, C.T. (deposition date: 2009-07-23, release date: 2010-01-26, Last modification date: 2023-11-01)
Primary citationTemperini, C.,Innocenti, A.,Scozzafava, A.,Parkkila, S.,Supuran, C.T.
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors
J.Med.Chem., 53:850-854, 2010
Cited by
PubMed: 20028100
DOI: 10.1021/jm901524f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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