6R4N

Crystal structure of S. cerevisia Niemann-Pick type C protein NPC2 with ergosterol bound

Summary for 6R4N

Entry DOI	10.2210/pdb6r4n/pdb
Related	6R4M
Descriptor	Phosphatidylglycerol/phosphatidylinositol transfer protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	vacuole, ergosterol, lipid transport
Biological source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Total number of polymer chains	9
Total formula weight	202037.03
Authors	Winkler, M.B.L.,Kidmose, R.T.,Pedersen, B.P. (deposition date: 2019-03-22, release date: 2019-09-25, Last modification date: 2020-07-29)
Primary citation	Winkler, M.B.L.,Kidmose, R.T.,Szomek, M.,Thaysen, K.,Rawson, S.,Muench, S.P.,Wustner, D.,Pedersen, B.P. Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins. Cell, 179:485-497.e18, 2019 Cited by PubMed: 31543266 DOI: 10.1016/j.cell.2019.08.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation