6R4N

Crystal structure of S. cerevisia Niemann-Pick type C protein NPC2 with ergosterol bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Phosphatidylglycerol/phosphatidylinositol transfer protein	polymer	201	21813.6	9	UniProt (Q12408) Pfam (PF02221)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PG/PI-TP,NPC2 homolog
2	J (J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
3	EA, GA, K, P, Q... (G, H, A, B, C...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
4	L, LA, R, U, X (A, I, C, E)	ERGOSTEROL	non-polymer		396.6	5	Chemie (ERG)
5	AA, BA, CA, DA, FA... (F, G, H, I, A...)	SULFATE ION	non-polymer		96.1	16	Chemie (SO4)

Sequence modifications

A, B, C, D, E, F, G, H, I: 1 - 173 (UniProt: Q12408)

PDB	External Database	Details
Leu 174	-	expression tag
Val 175	-	expression tag
Pro 176	-	expression tag
Arg 177	-	expression tag
Gly 178	-	expression tag
Ser 179	-	expression tag
Gly 180	-	expression tag
Gly 181	-	expression tag
Gly 182	-	expression tag
Gly 183	-	expression tag
Ser 184	-	expression tag
Gly 185	-	expression tag
Gly 186	-	expression tag
Gly 187	-	expression tag
Gly 188	-	expression tag
Ser 189	-	expression tag
Gly 190	-	expression tag
Gly 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag
His 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	196322.7
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	29
	Total formula weight	5289.9
All*	Total formula weight	202037.0

*Water molecules are not included.