6ER5

X-ray structure of Trypanothione Reductase from Leishmania infantum in complex with 2-(diethylamino)ethyl 4-((3-(4-nitrophenyl)-3-oxopropyl)amino)benzoate

Summary for 6ER5

Entry DOI	10.2210/pdb6er5/pdb
Descriptor	Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, 2-(diethylamino)ethyl 4-((3-(4-nitrophenyl)-3-oxopropyl)amino)benzoate, ... (4 entities in total)
Functional Keywords	trypanothione, trypanothione reductase, leishmania infantum trypanothione reductase inhibitors., oxidoreductase
Biological source	Leishmania infantum
Total number of polymer chains	1
Total formula weight	54162.99
Authors	Ilari, A.,Fiorillo, A. (deposition date: 2017-10-17, release date: 2018-10-31, Last modification date: 2024-01-17)
Primary citation	Turcano, L.,Torrente, E.,Missineo, A.,Andreini, M.,Gramiccia, M.,Di Muccio, T.,Genovese, I.,Fiorillo, A.,Harper, S.,Bresciani, A.,Colotti, G.,Ilari, A. Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening. Plos Negl Trop Dis, 12:e0006969-e0006969, 2018 Cited by PubMed: 30475811 DOI: 10.1371/journal.pntd.0006969 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.37 Å)

Structure validation