6EQU

X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor

Summary for 6EQU

Entry DOI	10.2210/pdb6equ/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-[2-(2,4,6-triphenylpyridin-1-ium-1-yl)ethyl]benzenesulfonamide, ... (4 entities in total)
Functional Keywords	human carbonic anhydrase ii, membrane-impermeant inhibitor, complex, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29903.14
Authors	Alterio, V.,De Simone, G.,Esposito, D. (deposition date: 2017-10-15, release date: 2017-12-13, Last modification date: 2024-01-17)
Primary citation	Alterio, V.,Esposito, D.,Monti, S.M.,Supuran, C.T.,De Simone, G. Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor. J Enzyme Inhib Med Chem, 33:151-157, 2018 Cited by PubMed: 29199489 DOI: 10.1080/14756366.2017.1405263 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation