PDB: 1828 件ウェブページステータス検索Chemie searchBIRD

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5K3L	Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with 444 分子名称: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Nuclear receptor ROR-gamma 著者 Huang, P, Rastinejad, F. 登録日 2016-05-19 公開日 2017-05-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with 444 To be published
6C5T	PPARg LBD bound to SR11023 分子名称: 2-{4-[(5-{[(1R)-1-(3-cyclopropylphenyl)ethyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]phenyl}-2-methylpropanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Bruning, J.B, Frkic, R.L, Griffin, P.R. 登録日 2018-01-16 公開日 2018-08-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 PPAR gamma in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix. iScience, 5, 2018
4DK8	Crystal structure of LXR ligand binding domain in complex with partial agonist 5 分子名称: ACETATE ION, CALCIUM ION, N-methyl-N-(4-{(1S)-2,2,2-trifluoro-1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]ethyl}phenyl)benzenesulfonamide, ... 著者 Piper, D.E, Kopecky, D.J, Xu, H. 登録日 2012-02-03 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Discovery of a new binding mode for a series of liver X receptor agonists. Bioorg.Med.Chem.Lett., 22, 2012
2NXX	Crystal Structure of the Ligand-Binding Domains of the T.castaneum (Coleoptera) Heterodimer EcrUSP Bound to Ponasterone A 分子名称: 2,3,14,20,22-PENTAHYDROXYCHOLEST-7-EN-6-ONE, Ecdysone Receptor (EcR, NRH1), ... 著者 Iwema, T, Billas, I, Moras, D. 登録日 2006-11-20 公開日 2007-10-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor. Embo J., 26, 2007
8SVQ	Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-312 分子名称: (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
6FOB	Vitamin D receptor complex 5 分子名称: (1~{R},3~{S},5~{Z})-4-methylidene-5-[(~{E})-3-[3-(6-methyl-6-oxidanyl-heptyl)phenyl]dec-2-enylidene]cyclohexane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A 著者 Rochel, N. 登録日 2018-02-06 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists. J. Med. Chem., 61, 2018
5Z12	A structure of FXR/RXR 分子名称: (9cis)-retinoic acid, 1-methylethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate, Bile acid receptor, ... 著者 Lu, Y, Li, Y. 登録日 2017-12-23 公開日 2018-07-04 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR J. Biol. Chem., 293, 2018
4DQM	Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity 分子名称: (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, Nuclear receptor coactivator 1, Retinoic acid receptor alpha 著者 Wang, S, Wang, Z, Lin, S, Zheng, W, Wang, R, Jin, S, Chen, J, Jin, L, Li, Y. 登録日 2012-02-16 公開日 2012-10-03 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem.J., 446, 2012
4RUP	Crystal structure of zVDR L337H mutant-Gemini72 complex 分子名称: (1R,3R,7E,17beta)-17-[(1R)-6,6,6-trifluoro-5-hydroxy-1-(4-hydroxy-4-methylpentyl)-5-(trifluoromethyl)hex-3-yn-1-yl]-9,1 0-secoestra-5,7-diene-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A 著者 Huet, T, Moras, D, Rochel, N. 登録日 2014-11-21 公開日 2015-10-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell Rep, 10, 2015
5DV8	Human PPARgamma ligand binding dmain complexed with SB1451 in a covalent bonded form 分子名称: N-[2-({2-[({4-[(4-methylpiperazin-1-yl)methyl]benzoyl}amino)methyl]benzyl}oxy)phenyl]-3-nitrobenzamide, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma 著者 Jang, J.Y. 登録日 2015-09-21 公開日 2016-09-21 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Human PPARgamma ligand binding dmain complexed with SB1451 in a covalent bonded form To Be Published
2VV2	hPPARgamma Ligand binding domain in complex with 5-HEPA 分子名称: (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA 著者 Itoh, T, Fairall, L, Schwabe, J.W.R. 登録日 2008-06-02 公開日 2008-08-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural Basis for the Activation of Pparg by Oxidised Fatty Acids Nat.Struct.Mol.Biol., 15, 2008
5DV3	Human PPARgamma ligand binding dmain complexed with SB1405 in a covalent bonded form 分子名称: N-[2-(benzyloxy)phenyl]-3-nitrobenzamide, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma 著者 Jang, J.Y. 登録日 2015-09-21 公開日 2016-09-21 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Human PPARgamma ligand binding dmain complexed with SB1405 in a covalent bonded form To Be Published
6KTN	Human PPARgamma ligand-binding domain R288A mutant in complex with imatinib 分子名称: 16-mer peptide from Nuclear receptor coactivator 1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Peroxisome proliferator-activated receptor gamma 著者 Jang, J.Y, Han, B.W. 登録日 2019-08-28 公開日 2020-02-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.752 Å) 主引用文献 Structural Basis for the Regulation of PPAR gamma Activity by Imatinib. Molecules, 24, 2019
7QAA	Crystal structure of RARalpha/RXRalpha ligand binding domain heterodimer in complex with BMS614 and oleic acid 分子名称: 4-[(4,4-DIMETHYL-1,2,3,4-TETRAHYDRO-[1,2']BINAPTHALENYL-7-CARBONYL)-AMINO]-BENZOIC ACID, Isoform Alpha-1-deltaBC of Retinoic acid receptor alpha, OLEIC ACID, ... 著者 le Maire, A, Vivat, V, Guee, L, Blanc, P, Malosse, C, Chamot-Rooke, J, Germain, P, Bourguet, w. 登録日 2021-11-16 公開日 2022-10-05 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids. J.Mol.Endocrinol., 69, 2022
7C6Q	Novel natural PPARalpha agonist with a unique binding mode 分子名称: 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, Peroxisome proliferator-activated receptor alpha 著者 Tian, S.Y, Wang, R, Zheng, W.L, Li, Y. 登録日 2020-05-22 公開日 2021-05-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Structural Basis for PPARs Activation by The Dual PPAR alpha / gamma Agonist Sanguinarine: A Unique Mode of Ligand Recognition. Molecules, 26, 2021
3TX7	Crystal structure of LRH-1/beta-catenin complex 分子名称: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Catenin beta-1, Nuclear receptor subfamily 5 group A member 2 著者 Yumoto, F, Fletterick, R. 登録日 2011-09-22 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Structural basis of coactivation of liver receptor homolog-1 by beta-catenin. Proc.Natl.Acad.Sci.USA, 109, 2012
1ILH	Crystal Structure of Human Pregnane X Receptor Ligand Binding Domain Bound to SR12813 分子名称: ORPHAN NUCLEAR RECEPTOR PXR, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER 著者 Watkins, R.E, Redinbo, M.R. 登録日 2001-05-08 公開日 2001-06-27 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science, 292, 2001
6L38	X-ray structure of human PPARalpha ligand binding domain-GW9662-gemfibrozil co-crystals obtained by delipidation and co-crystallization 分子名称: 2-chloro-5-nitro-N-phenylbenzamide, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. 登録日 2019-10-09 公開日 2020-11-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.761 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
3ADU	Human PPARgamma ligand-binding domain in complex with 5-methoxy-indole acetate 分子名称: (5-methoxy-1H-indol-3-yl)acetic acid, Peroxisome proliferator-activated receptor gamma 著者 Waku, T, Shiraki, T, Oyama, T, Morikawa, K. 登録日 2010-01-29 公開日 2010-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29, 2010
6O68	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Ciglitazone 分子名称: Ciglitazone, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2019-03-05 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Quantitative structural assessment of graded receptor agonism. Proc.Natl.Acad.Sci.USA, 116, 2019
4IS8	Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors 分子名称: Nuclear receptor subfamily 5 group A member 2 著者 Musille, P.M, Pathak, M.C, Ortlund, E.A. 登録日 2013-01-16 公開日 2013-06-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Divergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone Receptors. J.Biol.Chem., 288, 2013
4OED	Crystal structure of AR-LBD bound with co-regulator peptide 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Protein BUD31 homolog, ... 著者 Liu, J.S, Hsu, C.L, Wu, W.G. 登録日 2014-01-13 公開日 2014-08-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
3EYB	Structural and functional insights into the ligand binding domain of a non-duplicated RXR from the invertebrate chordate amphioxus 分子名称: Nuclear hormone receptor RXR 著者 Tocchini-Valentini, G.D, Rochel, N, Moras, D, Structural Proteomics in Europe (SPINE) 登録日 2008-10-20 公開日 2008-11-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus J.Biol.Chem., 284, 2009
3R8D	Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721 分子名称: 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE, Nuclear receptor subfamily 1 group I member 2 著者 Cheng, Y, Redinbo, M.R. 登録日 2011-03-23 公開日 2011-08-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci., 20, 2011
7E3M	RORgamma LBD complexed with Panaxatriol and SRC2.2 分子名称: (3R,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, Nuclear receptor ROR-gamma 著者 Liu, Z.H, Huang, J, Lu, W.Q, Tang, Y, Wu, Z.R. 登録日 2021-02-09 公開日 2022-03-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of human RORgammat LBD with SRC2.2 at 2.80 Angstroms resolution To Be Published

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