6KTN

Human PPARgamma ligand-binding domain R288A mutant in complex with imatinib

Summary for 6KTN

• Entry DOI: 10.2210/pdb6ktn/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 16-mer peptide from Nuclear receptor coactivator 1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (4 entities in total)
• Functional Keywords: type 2 diabetes mellitus, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 34593.03

Authors

Jang, J.Y.,Han, B.W. (deposition date: 2019-08-28, release date: 2020-02-05, Last modification date: 2023-11-22)

• Primary citation: Jang, J.Y.,Kim, H.J.,Han, B.W.; Structural Basis for the Regulation of PPAR gamma Activity by Imatinib.; Molecules, 24:-, 2019; PubMed: 31581474; DOI: 10.3390/molecules24193562

Experimental method

X-RAY DIFFRACTION (2.752 Å)