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6KTN

Human PPARgamma ligand-binding domain R288A mutant in complex with imatinib

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue STI A 501
ChainResidue
ALEU228
AILE341
ASER342
AMET364
AHOH601
AGLU259
AILE262
ALYS263
ALYS265
AGLY284
ACYS285
AMET329
ALEU333

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER698
AHIS323
AHIS449
ATYR473

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224

226707

PDB entries from 2024-10-30

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