4RUP

Crystal structure of zVDR L337H mutant-Gemini72 complex

Summary for 4RUP

Related2HC4 2HCD 4RUJ 4RUO
DescriptorVitamin D3 receptor A, Nuclear receptor coactivator 1, (1R,3R,7E,17beta)-17-[(1R)-6,6,6-trifluoro-5-hydroxy-1-(4-hydroxy-4-methylpentyl)-5-(trifluoromethyl)hex-3-yn-1-yl]-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
Functional Keywordsalpha helical sandwich, transcription factor, retinoid x receptor, ligand, dna, phosphorylation, nucleus
Biological sourceDanio rerio (leopard danio,zebra danio,zebra fish)
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Cellular locationNucleus Q9PTN2 Q15788
Total number of polymer chains2
Total molecular weight36456.4
Authors
Huet, T.,Moras, D.,Rochel, N. (deposition date: 2014-11-21, release date: 2015-10-07)
Primary citation
Huet, T.,Laverny, G.,Ciesielski, F.,Molnar, F.,Ramamoorthy, T.G.,Belorusova, A.Y.,Antony, P.,Potier, N.,Metzger, D.,Moras, D.,Rochel, N.
A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.
Cell Rep, 10:516-526, 2015
PubMed: 25620699 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2014.12.045
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.250110.4%4.9%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution