Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide

Summary for 2HCD

Related1DB1 2HBH 2HC4
DescriptorVitamin D receptor, SRC-1 from Nuclear receptor coactivator 1, 21-NOR-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, 20-(4-HYDROXY-4-METHYLPENTYL)-, (1A,3B,5Z,7E), ... (4 entities in total)
Functional Keywordsalpha helical sandwich, gene regulation
Biological sourceDanio rerio (zebrafish)
Cellular locationNucleus Q9PTN2
Nucleus (By similarity) Q15788
Total number of polymer chains2
Total molecular weight36339.51
Ciesielski, F.,Rochel, N.,Moras, D. (deposition date: 2006-06-16, release date: 2007-05-01, Last modification date: 2011-07-13)
Primary citation
Ciesielski, F.,Rochel, N.,Moras, D.
Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation
J.Steroid Biochem.Mol.Biol., 103:235-242, 2007
PubMed: 17218092 (PDB entries with the same primary citation)
DOI: 10.1016/j.jsbmb.2006.12.003
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.262241.6%9.9%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution