2HCD
Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D receptor | polymer | 302 | 34060.7 | 1 | UniProt (Q9PTN2) Pfam (PF00104) | Danio rerio (zebrafish) | |
| 2 | B (B) | SRC-1 from Nuclear receptor coactivator 1 | polymer | 15 | 1776.1 | 1 | UniProt (Q15788) | Homo sapiens | NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, NY-REN-52 antigen |
| 3 | C (A) | 21-NOR-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, 20-(4-HYDROXY-4-METHYLPENTYL)-, (1A,3B,5Z,7E) | non-polymer | 502.8 | 1 | Chemie (BIV) | |||
| 4 | D (A) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A: 156 - 453 (UniProt: Q9PTN2)
| PDB | External Database | Details |
|---|---|---|
| Gly 152 | - | cloning artifact |
| Ser 153 | - | cloning artifact |
| His 154 | - | cloning artifact |
| Met 155 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35836.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 502.8 | |
| All* | Total formula weight | 36339.5 |
