2HCD
Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D receptor | polymer | 302 | 34060.7 | 1 | UniProt (Q9PTN2) Pfam (PF00104) | Danio rerio (zebrafish) | |
| 2 | B (B) | SRC-1 from Nuclear receptor coactivator 1 | polymer | 15 | 1776.1 | 1 | UniProt (Q15788) | Homo sapiens | NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, NY-REN-52 antigen |
| 3 | C (A) | 21-NOR-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, 20-(4-HYDROXY-4-METHYLPENTYL)-, (1A,3B,5Z,7E) | non-polymer | 502.8 | 1 | Chemie (BIV) PubChem (44339465) PubChem (54449096) PubChem (54449097) PubChem (54449098) PubChem (57018183) PubChem (59842245) PubChem (59842275) PubChem (87473046) PubChem (87495468) PubChem (87557374) PubChem (89226433) PubChem (90941488) PubChem (91059272) PubChem (91381823) PubChem (101112476) PubChem (101746524) PubChem (101746532) PubChem (117789129) PubChem (9827416) PubChem (10074789) PubChem (10255503) PubChem (10436120) PubChem (10940075) PubChem (15450401) PubChem (142965988) PubChem (142966009) | |||
| 4 | D (A) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A: 156 - 453 (UniProt: Q9PTN2)
| PDB | External Database | Details |
|---|---|---|
| Gly 152 | - | cloning artifact |
| Ser 153 | - | cloning artifact |
| His 154 | - | cloning artifact |
| Met 155 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35836.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 502.8 | |
| All* | Total formula weight | 36339.5 |
