7C6Q

Novel natural PPARalpha agonist with a unique binding mode

Summary for 7C6Q

• Entry DOI: 10.2210/pdb7c6q/pdb
• Descriptor: Peroxisome proliferator-activated receptor alpha, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium, ... (4 entities in total)
• Functional Keywords: agonist, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 33354.75

Authors

Tian, S.Y.,Wang, R.,Zheng, W.L.,Li, Y. (deposition date: 2020-05-22, release date: 2021-05-26, Last modification date: 2023-11-29)

• Primary citation: Tian, S.,Wang, R.,Chen, S.,He, J.,Zheng, W.,Li, Y.; Structural Basis for PPARs Activation by The Dual PPAR alpha / gamma Agonist Sanguinarine: A Unique Mode of Ligand Recognition.; Molecules, 26:-, 2021; PubMed: 34641558; DOI: 10.3390/molecules26196012

Experimental method

X-RAY DIFFRACTION (2.76 Å)