PDB: 45176 件ウェブページステータス検索Chemie searchBIRD

---

3RAI	CDK2 in complex with inhibitor KVR-1-160 分子名称: 1,2-ETHANEDIOL, 4-{[3-(morpholin-4-yl)propyl]amino}-5-nitro-2-[(pyridin-3-ylmethyl)amino]benzamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-03-28 公開日 2012-08-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
3RAK	CDK2 in complex with inhibitor RC-2-32 分子名称: 4-[(4-amino-5-benzoyl-1,3-thiazol-2-yl)amino]benzenesulfonamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-03-28 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3P2H	Crystal structure of TofI in a ternary complex with an inhibitor and MTA 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, AHL synthase, N-(3-oxocyclohex-1-en-1-yl)octanamide 著者 Yu, S, Rhee, S. 登録日 2010-10-02 公開日 2011-07-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase Proc.Natl.Acad.Sci.USA, 108, 2011
3RM6	CDK2 in complex with inhibitor KVR-2-80 分子名称: 1,2-ETHANEDIOL, 2-{[(2-aminopyrimidin-5-yl)methyl]amino}-5-nitro-4-{[2-(piperazin-1-yl)ethyl]amino}benzamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-04-20 公開日 2012-08-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening To be Published
2WIC	Crystal Structures of the N-terminal Intracellular Domain of FeoB from Klebsiella Pneumoniae in GMPPNP binding state 分子名称: FERROUS IRON TRANSPORT PROTEIN B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Hung, K.-W, Chang, Y.-W, Chen, J.-H, Chen, Y.-C, Sun, Y.-J, Hsiao, C.-D, Huang, T.-H. 登録日 2009-05-09 公開日 2010-05-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural Fold, Conservation and Fe(II) Binding of the Intracellular Domain of Prokaryote Feob. J.Struct.Biol., 170, 2010
3X2S	Crystal structure of pyrene-conjugated adenylate kinase 分子名称: Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... 著者 Fujii, A, Sekiguchi, Y, Matsumura, H, Inoue, T, Chung, W.-S, Hirota, S, Matsuo, T. 登録日 2014-12-31 公開日 2015-04-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Excimer Emission Properties on Pyrene-Labeled Protein Surface: Correlation between Emission Spectra, Ring Stacking Modes, and Flexibilities of Pyrene Probes. Bioconjug.Chem., 26, 2015
3PAH	HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND ADRENALINE INHIBITOR 分子名称: 4-[(1S)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol, FE (III) ION, PHENYLALANINE HYDROXYLASE 著者 Erlandsen, H, Flatmark, T, Stevens, R.C. 登録日 1998-08-20 公開日 1999-04-27 最終更新日 2013-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution. Biochemistry, 37, 1998
3ZNC	MURINE CARBONIC ANHYDRASE IV COMPLEXED WITH BRINZOLAMIDE 分子名称: (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE IV, ZINC ION 著者 Stams, T, Chen, Y, Christianson, D.W. 登録日 1998-02-10 公開日 1999-03-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci., 7, 1998
3X43	Crystal structure of O-ureido-L-serine synthase 分子名称: O-ureido-L-serine synthase, PYRIDOXAL-5'-PHOSPHATE 著者 Matoba, Y, Uda, N, Oda, K, Sugiyama, M. 登録日 2015-03-13 公開日 2015-07-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The structural and mutational analyses of O-ureido-L-serine synthase necessary for D-cycloserine biosynthesis. Febs J., 282, 2015
3P3N	Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1930-1949) peptide 分子名称: 2-OXOGLUTARIC ACID, FE (II) ION, GLYCEROL, ... 著者 McDonough, M.A, Schofield, C.J. 登録日 2010-10-05 公開日 2010-11-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor J.Biol.Chem., 282, 2007
3ZQE	PrgI-SipD from Salmonella typhimurium in complex with deoxycholate 分子名称: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCEROL, PROTEIN PRGI, ... 著者 Lunelli, M, Kolbe, M. 登録日 2011-06-09 公開日 2011-08-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Crystal Structure of Prgi-Sipd: Insight Into a Secretion Competent State of the Type Three Secretion System Needle Tip and its Interaction with Host Ligands Plos Pathog., 7, 2011
4A4D	Crystal structure of the N-terminal domain of the Human DEAD-BOX RNA helicase DDX5 (P68) 分子名称: PROBABLE ATP-DEPENDENT RNA HELICASE DDX5 著者 Dutta, S, Choi, Y.W, Kotaka, M, Fielding, B.C, Tan, Y.J. 登録日 2011-10-11 公開日 2012-08-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The Variable N-Terminal Region of Ddx5 Contains Structural Elements and Auto-Inhibits its Interaction with Ns5B of Hepatitis C Virus. Biochem.J., 446, 2012
4AED	Crystal structure of Human enterovirus 71 分子名称: CALCIUM ION, LAURIC ACID, VP1, ... 著者 Plevka, P, Perera, R, Kuhn, R.J, Rossmann, M.G. 登録日 2012-01-09 公開日 2012-04-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Crystal Structure of Human Enterovirus 71. Science, 336, 2012
3MY6	Crystal Structure of the complex of type 1 ribosome inactivating protein with 7-methylguanine at 2.65 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one, Ribosome-inactivating protein momordin I 著者 Kushwaha, G.S, Singh, N, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Singh, T.P. 登録日 2010-05-10 公開日 2010-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Crystal Structure of the complex of type 1 ribosome inactivating protein with 7-methylguanine at 2.65 A resolution To be Published
2V9G	L-RHAMNULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI (MUTANT Q6Y- L84W-E192A) 分子名称: L(+)-TARTARIC ACID, RHAMNULOSE-1-PHOSPHATE ALDOLASE, ZINC ION 著者 Grueninger, D, Schulz, G.E. 登録日 2007-08-23 公開日 2008-01-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Designed Protein-Protein Association. Science, 319, 2008
3RZB	CDK2 in complex with inhibitor RC-2-23 分子名称: 4-amino-2-(phenylamino)-1,3-thiazole-5-carboxamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-05-11 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
3S00	CDK2 in complex with inhibitor L4-14 分子名称: Cyclin-dependent kinase 2, [4-amino-2-(prop-2-en-1-ylamino)-1,3-thiazol-5-yl](5-chlorothiophen-2-yl)methanone 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2011-05-12 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
4ANG	Small RNA phage PRR1 in complex with an RNA operator fragment 分子名称: 5'-R(*CP*CP*AP*UP*AP*AP*GP*GP*AP*GP*CP*UP*AP*CP *CP*UP*AP*UP*GP*GP)-3', CALCIUM ION, COAT PROTEIN 著者 Persson, M, Tars, K, Liljas, L. 登録日 2012-03-16 公開日 2013-02-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Prr1 Coat Protein Binding to its RNA Translational Operator Acta Crystallogr.,Sect.D, 69, 2013
3N7M	Crystal structure of W1252A mutant of HCR D/C VPI 5995 分子名称: GLYCEROL, Neurotoxin, SULFATE ION 著者 Fu, Z, Karalewitz, A, Kroken, A, Baldwin, M.R, Barbieri, J.T, Kim, J.-J.P. 登録日 2010-05-27 公開日 2010-09-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA . Biochemistry, 49, 2010
4AGC	CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH AXITINIB (AG-013736) (N-Methyl-2-(3-((E)-2-pyridin-2-yl- vinyl)-1H-indazol-6-ylsulfanyl)-benzamide) 分子名称: AXITINIB, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 著者 Mctigue, M, Deng, Y, Ryan, K, Brooun, A, Diehl, W, Kania, R.S. 登録日 2012-01-26 公開日 2012-09-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.USA, 109, 2012
479D	CRYSTAL STRUCTURE A DNA:RNA HYBRID DUPLEX, A DYNAMIC MODEL FOR RNASE H RECOGNITION 分子名称: DNA (5'-D(*CP*TP*CP*TP*TP*CP*TP*TP*C)-3'), RNA (5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*G)-3') 著者 Xiong, Y, Sundaralingam, M. 登録日 1999-07-08 公開日 2000-05-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of a DNA.RNA hybrid duplex with a polypurine RNA r(gaagaagag) and a complementary polypyrimidine DNA d(CTCTTCTTC). Nucleic Acids Res., 28, 2000
4AG4	Crystal structure of a DDR1-Fab complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1, ... 著者 Carafoli, F, Mayer, M.C, Shiraishi, K, Pecheva, M.A, Chan, L.Y, Nan, R, Leitinger, B, Hohenester, E. 登録日 2012-01-24 公開日 2012-04-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling. Structure, 20, 2012
4A37	Metallo-carboxypeptidase from Pseudomonas Aeruginosa 分子名称: METALLO-CARBOXYPEPTIDASE, ZINC ION 著者 Otero, A, Rodriguez de la Vega, M, Tanco, S.M, Lorenzo, J, Aviles, F.X, Reverter, D. 登録日 2011-09-30 公開日 2012-05-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The Novel Structure of a Cytosolic M14 Metallocarboxypeptidase (Ccp) from Pseudomonas Aeruginosa: A Model for Mammalian Ccps. Faseb J., 26, 2012
3QQ5	Crystal structure of the [FeFe]-hydrogenase maturation protein HydF 分子名称: Small GTP-binding protein 著者 Cendron, L, Berto, P, D'Adamo, S, Vallese, F, Govoni, C, Posewitz, M.C, Giacometti, G.M, Costantini, P, Zanotti, G. 登録日 2011-02-15 公開日 2011-11-16 最終更新日 2012-01-11 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Crystal Structure of HydF Scaffold Protein Provides Insights into [FeFe]-Hydrogenase Maturation. J.Biol.Chem., 286, 2011
4APP	Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide 分子名称: GLYCEROL, N-[6,6-dimethyl-5-[(2S)-4-methyl-2-(phenylmethyl)piperazin-1-yl]carbonyl-2,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-phenoxy-benzamide, SERINE/THREONINE-PROTEIN KINASE PAK 4 著者 Knighton, D.D, Deng, Y.L, Wang, C, Guo, C, McAlpine, I, Zhang, J, Kephart, S, Johnson, M.C, Li, H, Bouzida, D, Yang, A, Dong, L, Marakovits, J, Tikhe, J, Richardson, P, Guo, L.C, Kania, R, Edwards, M.P, Kraynov, E, Christensen, J, Piraino, J, Lee, J, Dagostino, E, Del-Carmen, C, Smeal, T, Murray, B.W. 登録日 2012-04-04 公開日 2012-06-06 最終更新日 2019-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Pyrroloaminopyrazoles as Novel Pak Inhibitors. J.Med.Chem., 55, 2012

<623624625626627628629630631632633634635636637638>