3P3N

Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1930-1949) peptide

Summary for 3P3N

• Entry DOI: 10.2210/pdb3p3n/pdb
• Related: 1H2K 1H2L 1H2M 2QC9 2ZGD 3D8C 3P3P
• Descriptor: Hypoxia-inducible factor 1-alpha inhibitor, Notch 1 protein, FE (II) ION, ... (7 entities in total)
• Functional Keywords: double stranded beta-helix, hydroxylase, iron binding, 2-oxoglutarate binding, hypoxia inducible factor binding, ankyrin repeat domain binding, oxidoreductase-transcription complex, oxidoreductase/transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Potential): Q9NWT6
• Total number of polymer chains: 2
• Total formula weight: 43252.04

Authors

McDonough, M.A.,Schofield, C.J. (deposition date: 2010-10-05, release date: 2010-11-24, Last modification date: 2023-09-06)

• Primary citation: Coleman, M.L.,Mcdonough, M.A.,Hewitson, K.S.,Coles, C.,Mecinovic, J.,Edelmann, M.,Cook, K.M.,Cockman, M.E.,Lancaster, D.E.,Kessler, B.M.,Oldham, N.J.,Ratcliffe, P.J.,Schofield, C.J.; Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor; J.Biol.Chem., 282:24027-24038, 2007; PubMed: 17573339

Experimental method

X-RAY DIFFRACTION (2.4 Å)