3P3N
Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1930-1949) peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0005112 | molecular_function | Notch binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019826 | molecular_function | oxygen sensor activity |
| A | 0030947 | biological_process | regulation of vascular endothelial growth factor receptor signaling pathway |
| A | 0031406 | molecular_function | carboxylic acid binding |
| A | 0036139 | molecular_function | peptidyl-histidine dioxygenase activity |
| A | 0036140 | molecular_function | [protein]-asparagine 3-dioxygenase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045663 | biological_process | positive regulation of myoblast differentiation |
| A | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050793 | biological_process | regulation of developmental process |
| A | 0051059 | molecular_function | NF-kappaB binding |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
| A | 0062101 | molecular_function | peptidyl-aspartic acid 3-dioxygenase activity |
| A | 0071532 | molecular_function | ankyrin repeat binding |
| A | 2001214 | biological_process | positive regulation of vasculogenesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE2 A 350 |
| Chain | Residue |
| A | HIS199 |
| A | ASP201 |
| A | HIS279 |
| A | HOH1071 |
| A | AKG1351 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | ARG138 |
| A | GLY140 |
| A | GLU141 |
| A | GLU142 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | LYS311 |
| A | ALA312 |
| A | HOH1117 |
| A | GOL2003 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AKG A 1351 |
| Chain | Residue |
| A | TYR145 |
| A | LEU188 |
| A | THR196 |
| A | HIS199 |
| A | ASP201 |
| A | ASN205 |
| A | PHE207 |
| A | LYS214 |
| A | HIS279 |
| A | ILE281 |
| A | ASN294 |
| A | TRP296 |
| A | FE2350 |
| A | HOH1071 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2000 |
| Chain | Residue |
| A | LYS99 |
| A | LEU101 |
| A | TYR230 |
| A | SER240 |
| A | GLN241 |
| A | ASP243 |
| A | HOH1008 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 2001 |
| Chain | Residue |
| A | PHE224 |
| A | LYS315 |
| A | MET319 |
| A | HOH1042 |
| A | HOH1043 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 2002 |
| Chain | Residue |
| A | PRO43 |
| A | ARG44 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 2003 |
| Chain | Residue |
| A | GLU60 |
| A | PRO220 |
| A | TRP277 |
| A | SO4402 |
| A | HOH1137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: (3S)-3-hydroxyasparagine; by HIF1AN; partial => ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578 |
| Chain | Residue | Details |
| B | ASN1945 | |
| A | THR196 | |
| A | ASN205 | |
| A | LYS214 | |
| A | ASN294 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21177872 |
| Chain | Residue | Details |
| A | ASP152 | |
| A | GLN181 | |
| A | ARG238 | |
| A | ALA300 | |
| A | ASN321 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 |
| Chain | Residue | Details |
| A | HIS199 | |
| A | ASP201 | |
| A | HIS279 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Important for dimer formation |
| Chain | Residue | Details |
| A | LEU340 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 |
