3ZNC

MURINE CARBONIC ANHYDRASE IV COMPLEXED WITH BRINZOLAMIDE

Summary for 3ZNC

• Entry DOI: 10.2210/pdb3znc/pdb
• Descriptor: CARBONIC ANHYDRASE IV, ZINC ION, (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, ... (4 entities in total)
• Functional Keywords: lyase, zinc, murine, membrane, inhibitor
• Biological source: Mus musculus (house mouse)
• Cellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity): Q64444
• Total number of polymer chains: 1
• Total formula weight: 29939.44

Authors

Stams, T.,Chen, Y.,Christianson, D.W. (deposition date: 1998-02-10, release date: 1999-03-23, Last modification date: 2011-07-13)

• Primary citation: Stams, T.,Chen, Y.,Boriack-Sjodin, P.A.,Hurt, J.D.,Liao, J.,May, J.A.,Dean, T.,Laipis, P.,Silverman, D.N.,Christianson, D.W.; Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.; Protein Sci., 7:556-563, 1998; PubMed: 9541386

Experimental method

X-RAY DIFFRACTION (2.8 Å)