4AT8
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6TXR
| Structural insights into cubane-modified aptamer recognition of a malaria biomarker | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ... | 著者 | Cheung, Y, Roethlisberger, P, Mechaly, A, Weber, P, Wong, A, Lo, Y, Haouz, A, Savage, P, Hollenstein, M, Tanner, J. | 登録日 | 2020-01-14 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker. Proc.Natl.Acad.Sci.USA, 117, 2020
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5G53
| Structure of the adenosine A2A receptor bound to an engineered G protein | 分子名称: | ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G. | 登録日 | 2016-05-19 | 公開日 | 2016-08-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein Nature, 536, 2016
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6U1F
| Thermus thermophilus D-alanine-D-alanine ligase in complex with ATP, D-alanine-D-alanine, Mg2+ and Cs+ | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CESIUM ION, D-ALANINE, ... | 著者 | Pederick, J.L, Bruning, J.B. | 登録日 | 2019-08-15 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations. J.Biol.Chem., 295, 2020
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6U3A
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6U39
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7MXE
| Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8ANC195 G52K5 Fab heavy chain, ... | 著者 | Abernathy, M.E, Bjorkman, P.J. | 登録日 | 2021-05-19 | 公開日 | 2021-10-27 | 最終更新日 | 2021-11-03 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope. Npj Vaccines, 6, 2021
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8U18
| Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor,GCN4 isoform 1, ... | 著者 | Sarson-Lawrence, K.S, Hardy, J.M, Leis, A, Babon, J.J, Kershaw, N.J. | 登録日 | 2023-08-30 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin. Nat Commun, 15, 2024
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6E7D
| Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain family 2 member D, Killer cell lectin-like receptor subfamily B member 1B allele B, ... | 著者 | Balaji, G.R, Rossjohn, J, Berry, R. | 登録日 | 2018-07-26 | 公開日 | 2018-10-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition. Nat Commun, 9, 2018
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4AT9
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6EEB
| Calmodulin in complex with malbrancheamide | 分子名称: | (5aS,12aS,13aS)-8,9-dichloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one, CALCIUM ION, Calmodulin-1, ... | 著者 | Beyett, T.S, Fraley, A.E, Tesmer, J.J.G. | 登録日 | 2018-08-13 | 公開日 | 2019-08-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proc.Natl.Acad.Sci.USA, 116, 2019
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6U1I
| Thermus thermophilus D-alanine-D-alanine ligase in complex with ADP, phosphorylated D-cycloserine, Mg2+ and K+ | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, D-alanine--D-alanine ligase, MAGNESIUM ION, ... | 著者 | Pederick, J.L, Bruning, J.B, Thompson, A.P. | 登録日 | 2019-08-15 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations. J.Biol.Chem., 295, 2020
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6U3B
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4BB6
| Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors | 分子名称: | 6-(4-methylpiperazin-1-yl)-N-[(1R,3S)-5-oxidanyl-2-adamantyl]-2-propylsulfanyl-pyridine-3-carboxamide, CHLORIDE ION, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, ... | 著者 | Goldberg, F.W, Leach, A.G, Scott, J.S, Snelson, W.L, Groombridge, S.D, Donald, C.S, Bennett, S.N.L, Bodin, C, Morentin Gutierrez, P, Gyte, A.C. | 登録日 | 2012-09-20 | 公開日 | 2012-11-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Free-Wilson and Structural Approaches to Co- Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors J.Med.Chem., 55, 2012
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4BL0
| Crystal structure of yeast Bub3-Bub1 bound to phospho-Spc105 | 分子名称: | CELL CYCLE ARREST PROTEIN BUB3, CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1, MAGNESIUM ION, ... | 著者 | Primorac, I, Weir, J.R, Musacchio, A. | 登録日 | 2013-04-30 | 公開日 | 2013-09-18 | 最終更新日 | 2013-10-09 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Bub3 Reads Phosphorylated Melt Repeats to Promote Spindle Assembly Checkpoint Signaling Elife, 2, 2013
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7MFE
| Autoinhibited BRAF:(14-3-3)2 complex with the BRAF RBD resolved | 分子名称: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf, ZINC ION | 著者 | Martinez Fiesco, J.A, Ping, Z, Durrant, D.E, Morrison, D.K. | 登録日 | 2021-04-09 | 公開日 | 2022-01-26 | 最終更新日 | 2022-02-09 | 実験手法 | ELECTRON MICROSCOPY (4.07 Å) | 主引用文献 | Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Nat Commun, 13, 2022
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7MFF
| Dimeric (BRAF)2:(14-3-3)2 complex bound to SB590885 Inhibitor | 分子名称: | (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME, 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | 著者 | Martinez Fiesco, J.A, Ping, Z, Durrant, D.E, Morrison, D.K. | 登録日 | 2021-04-09 | 公開日 | 2022-01-26 | 最終更新日 | 2022-02-09 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Nat Commun, 13, 2022
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7MFD
| Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved | 分子名称: | 14-3-3 protein zeta/delta, Dual specificity mitogen-activated protein kinase kinase 1, N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide, ... | 著者 | Martinez Fiesco, J.A, Ping, Z, Durrant, D.E, Morrison, D.K. | 登録日 | 2021-04-09 | 公開日 | 2022-01-26 | 最終更新日 | 2022-02-09 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Nat Commun, 13, 2022
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6JII
| Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | 登録日 | 2019-02-21 | 公開日 | 2019-07-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 572, 2019
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3ZHM
| N-terminal domain of the CI repressor from bacteriophage TP901-1 in complex with the OL2 operator half-site | 分子名称: | 5'-D(*AP*CP*GP*TP*GP*AP*AP*CP*TP*TP*GP*CP*AP*CP *TP*TP*GP*A)-3', 5'-D(*AP*GP*TP*TP*CP*AP*CP*GP*TP*TP*CP*AP*AP*GP *TP*GP*CP*A)-3', CI | 著者 | Frandsen, K.H, Rasmussen, K.K, Poulsen, J.N, Lo Leggio, L. | 登録日 | 2012-12-22 | 公開日 | 2013-12-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Binding of the N-Terminal Domain of the Lactococcal Bacteriophage Tp901-1 Ci Repressor to its Target DNA: A Crystallography, Small Angle Scattering, and Nuclear Magnetic Resonance Study. Biochemistry, 52, 2013
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6K4R
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6K4K
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5H8C
| Truncated XPD | 分子名称: | IRON/SULFUR CLUSTER, XPD/Rad3 related DNA helicase | 著者 | Naismith, J.H, Constantinescu, D. | 登録日 | 2015-12-23 | 公開日 | 2016-01-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Mechanism of DNA loading by the DNA repair helicase XPD. Nucleic Acids Res., 44, 2016
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5H8W
| XPD mechanism | 分子名称: | ATP-dependent DNA helicase Ta0057, DNA (5'-D(P*TP*AP*CP*GP*A)-3'), IRON/SULFUR CLUSTER, ... | 著者 | Naismith, J.H, Constantinescu, D. | 登録日 | 2015-12-24 | 公開日 | 2016-01-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mechanism of DNA loading by the DNA repair helicase XPD. Nucleic Acids Res., 44, 2016
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5XR2
| SAV0551 | 分子名称: | LACTIC ACID, Protein/nucleic acid deglycase HchA, ZINC ION | 著者 | Kim, H.J, Kwon, A.R, Lee, B.J. | 登録日 | 2017-06-07 | 公開日 | 2017-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and functional studies of SAV0551 fromStaphylococcus aureusas a chaperone and glyoxalase III. Biosci. Rep., 37, 2017
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