8U18

Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo

Summary for 8U18

• Entry DOI: 10.2210/pdb8u18/pdb
• EMDB information: 41805
• Descriptor: Thrombopoietin receptor,GCN4 isoform 1, Thrombopoietin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: receptor, cytokine, signalling, haematopoiesis, cytokine-receptor complex, cytokine/receptor
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 135149.25

Authors

Sarson-Lawrence, K.S.,Hardy, J.M.,Leis, A.,Babon, J.J.,Kershaw, N.J. (deposition date: 2023-08-30, release date: 2024-02-07, Last modification date: 2024-02-21)

• Primary citation: Sarson-Lawrence, K.T.G.,Hardy, J.M.,Iaria, J.,Stockwell, D.,Behrens, K.,Saiyed, T.,Tan, C.,Jebeli, L.,Scott, N.E.,Dite, T.A.,Nicola, N.A.,Leis, A.P.,Babon, J.J.,Kershaw, N.J.; Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin.; Nat Commun, 15:1135-1135, 2024; PubMed: 38326297; DOI: 10.1038/s41467-024-45356-2

Experimental method

ELECTRON MICROSCOPY (3.6 Å)