8U18
Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Thrombopoietin receptor,GCN4 isoform 1 | polymer | 503 | 56559.7 | 2 | UniProt (Q08351) UniProt (A0A8H8ULK5) Pfam (PF09067) | Mus musculus (house mouse) | TPO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl |
| 2 | C (C) | Thrombopoietin | polymer | 181 | 19611.7 | 1 | UniProt (P40226) Pfam (PF00758) | Mus musculus (house mouse) | C-mpl ligand,ML,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,MGDF,Myeloproliferative leukemia virus oncogene ligand |
| 3 | D, E (D, E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | F, G, I, J (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | H, K (A, B) | alpha-D-mannopyranose | non-polymer | 180.2 | 2 | Chemie (MAN) |
Sequence modifications
A, B: 26 - 482 (UniProt: Q08351)
A, B: 483 - 515 (UniProt: A0A8H8ULK5)
C: 22 - 184 (UniProt: P40226)
A, B: 483 - 515 (UniProt: A0A8H8ULK5)
| PDB | External Database | Details |
|---|---|---|
| Thr 516 | - | expression tag |
| Gly 517 | - | expression tag |
| Thr 518 | - | expression tag |
| Gly 519 | - | expression tag |
| Gly 520 | - | expression tag |
| Ala 521 | - | expression tag |
| Pro 522 | - | expression tag |
| Glu 523 | - | expression tag |
| Asn 524 | - | expression tag |
| Leu 525 | - | expression tag |
| Tyr 526 | - | expression tag |
| Phe 527 | - | expression tag |
| Gln 528 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 4 | - | expression tag |
| Ser 5 | - | expression tag |
| Ile 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Ala 8 | - | expression tag |
| Arg 9 | - | expression tag |
| Gln 10 | - | expression tag |
| Asp 11 | - | expression tag |
| Tyr 12 | - | expression tag |
| Lys 13 | - | expression tag |
| Asp 14 | - | expression tag |
| Asp 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Lys 18 | - | expression tag |
| Thr 19 | - | expression tag |
| Arg 20 | - | expression tag |
| Gln 21 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 132731.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1245.1 | |
| All* | Total formula weight | 135149.3 |
