8U18
Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo
Functional Information from PROSITE/UniProt
| site_id | PS00817 |
| Number of Residues | 28 |
| Details | EPO_TPO Erythropoietin / thrombopoeitin signature. PvapaCDpRLLnKllrdshllhsrlsqC |
| Chain | Residue | Details |
| C | PRO23-CYS50 |
| site_id | PS01352 |
| Number of Residues | 78 |
| Details | HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LeLeWqhqsswaaqetc....YQLrytgegredwkvlepslgarggtle..LrpraryslqlRaRlngptyqgpWsaWspparV |
| Chain | Residue | Details |
| A | LEU397-VAL474 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 912 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN26-TRP482 | |
| B | GLN26-TRP482 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN117 | |
| B | ASN117 |
