7MXE

Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab

Summary for 7MXE

• Entry DOI: 10.2210/pdb7mxe/pdb
• EMDB information: 24072
• Descriptor: 8ANC195 G52K5 Fab heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: viral protein-immune system complex, non-neutralizing, antiviral protein, antiviral protein-viral protein complex, antiviral protein/viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 14
• Total formula weight: 440649.06

Authors

Abernathy, M.E.,Bjorkman, P.J. (deposition date: 2021-05-19, release date: 2021-10-27, Last modification date: 2021-11-03)

• Primary citation: Abernathy, M.E.,Gristick, H.B.,Vielmetter, J.,Keeffe, J.R.,Gnanapragasam, P.N.P.,Lee, Y.E.,Escolano, A.,Gautam, R.,Seaman, M.S.,Martin, M.A.,Nussenzweig, M.C.,Bjorkman, P.J.; Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope.; Npj Vaccines, 6:126-126, 2021; PubMed: 34697307; DOI: 10.1038/s41541-021-00387-4

Experimental method

ELECTRON MICROSCOPY (3.7 Å)