7MXE

Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, H, M	8ANC195 G52K5 Fab heavy chain	polymer	244	26153.3	3		Homo sapiens
2	B, L, O	8ANC195 G52K5 Fab light chain	polymer	215	23460.0	3		Homo sapiens
3	C, D, F	HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41	polymer	153	17146.5	3	UniProt (Q2N0S6) Pfam (PF00517) In PDB	Human immunodeficiency virus 1 (HIV-1)
4	G, J, P	Envelope glycoprotein BG505 SOSIP.664 gp120	polymer	479	53864.1	3	UniProt (Q2N0S6) Pfam (PF00516) In PDB	Human immunodeficiency virus 1	Env polyprotein
5	R	Ab1245 Fab heavy chain	polymer	263	28154.8	1		Macaca mulatta
6	W	Ab1245 Fab light chain	polymer	241	25306.2	1		Macaca mulatta
7	a, b, c, d, e...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	21	In PDB GlyTouCan (G42666HT)
8	V	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
9	X	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G56014GC)
10	Y	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1883.7	1	In PDB GlyTouCan (G60230HH)
11	h, s	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)
12	i, r	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1721.5	2	In PDB GlyTouCan (G40702WU)
13	j, k, p, q	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
14	G, J, P, C, F	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	23	Chemie (NAG)

Sequence modifications

C, D, F: 512 - 664 (UniProt: Q2N0S6)

PDB	External Database	Details
Pro 559	Ile 556	engineered mutation
Cys 605	Thr 602	engineered mutation

G, J, P: 33 - 513 (UniProt: Q2N0S6)

PDB	External Database	Details
Asn 332	Thr 330	engineered mutation
Cys 501	Ala 498	engineered mutation
Arg 509	Glu 506	engineered mutation
Arg 510	Lys 507	engineered mutation
Arg 511	-	insertion
Arg 512	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	415332.7
Branched	Number of molecules	32
	Total formula weight	20228.6
Non-Polymers*	Number of molecules	23
	Total formula weight	5087.8
All*	Total formula weight	440649.1

*Water molecules are not included.