7MXE
Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, J (A, H, M) | 8ANC195 G52K5 Fab heavy chain | polymer | 244 | 26153.3 | 3 | Homo sapiens | ||
| 2 | B, I, K (B, L, O) | 8ANC195 G52K5 Fab light chain | polymer | 215 | 23460.0 | 3 | Homo sapiens | ||
| 3 | C, D, E (C, D, F) | HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 (HIV-1) | |
| 4 | F, H, L (G, J, P) | Envelope glycoprotein BG505 SOSIP.664 gp120 | polymer | 479 | 53864.1 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | Env polyprotein |
| 5 | M (R) | Ab1245 Fab heavy chain | polymer | 263 | 28154.8 | 1 | Macaca mulatta | ||
| 6 | N (W) | Ab1245 Fab light chain | polymer | 241 | 25306.2 | 1 | Macaca mulatta | ||
| 7 | AA, BA, CA, DA, EA... (a, b, c, d, e...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 21 | In PDB GlyTouCan (G42666HT) | |||
| 8 | W (V) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 9 | X (X) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 10 | Y (Y) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 1 | In PDB GlyTouCan (G60230HH) | |||
| 11 | HA, SA (h, s) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 12 | IA, RA (i, r) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 2 | In PDB GlyTouCan (G40702WU) | |||
| 13 | JA, KA, PA, QA (j, k, p, q) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 14 | AB, BB, CB, DB, EB... (G, J, P, C, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 23 | Chemie (NAG) |
Sequence modifications
C, D, F: 512 - 664 (UniProt: Q2N0S6)
G, J, P: 33 - 513 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | engineered mutation |
| Cys 605 | Thr 602 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
| Arg 509 | Glu 506 | engineered mutation |
| Arg 510 | Lys 507 | engineered mutation |
| Arg 511 | - | insertion |
| Arg 512 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 415332.7 | |
| Branched | Number of molecules | 32 |
| Total formula weight | 20228.6 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 5087.8 | |
| All* | Total formula weight | 440649.1 |
