7MFF

Dimeric (BRAF)2:(14-3-3)2 complex bound to SB590885 Inhibitor

Summary for 7MFF

Entry DOI	10.2210/pdb7mff/pdb
EMDB information	23815
Descriptor	14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf, (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME (3 entities in total)
Functional Keywords	b-raf, 14-3-3, b-raf complex, b-raf dimer, active b-raf, sb590885, signaling protein, serine/threonine-protein kinase b-raf
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	225856.65
Authors	Martinez Fiesco, J.A.,Ping, Z.,Durrant, D.E.,Morrison, D.K. (deposition date: 2021-04-09, release date: 2022-01-26, Last modification date: 2022-02-09)
Primary citation	Martinez Fiesco, J.A.,Durrant, D.E.,Morrison, D.K.,Zhang, P. Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Nat Commun, 13:486-486, 2022 Cited by PubMed: 35078985 DOI: 10.1038/s41467-022-28084-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.89 Å)

Structure validation