7M4P
 
 | | Multidrug Efflux pump AdeJ with Eravacycline bound | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Efflux pump membrane transporter, Eravacycline | | 著者 | Zhang, Z. | | 登録日 | 2021-03-22 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii.
Mbio, 12, 2021
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7M4Q
 | | Multidrug Efflux pump AdeJ | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Efflux pump membrane transporter | | 著者 | Zhang, Z. | | 登録日 | 2021-03-22 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | | 主引用文献 | Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii.
Mbio, 12, 2021
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7RY3
 | | Multidrug Efflux pump AdeJ with TP-6076 bound | | 分子名称: | (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, Efflux pump membrane transporter | | 著者 | Zhang, Z. | | 登録日 | 2021-08-24 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii.
Mbio, 13, 2022
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7RR7
 | | Multidrug efflux pump subunit AcrB | | 分子名称: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | | 著者 | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | | 登録日 | 2021-08-09 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Multidrug efflux pump subunit AcrB
To Be Published
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7RR8
 | | Multidrug efflux pump subunit AcrB | | 分子名称: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | | 著者 | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | | 登録日 | 2021-08-09 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | | 主引用文献 | Multidrug efflux pump subunit AcrB
To Be Published
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7RR6
 | | Multidrug efflux pump subunit AcrB | | 分子名称: | DODECANE, Multidrug efflux pump subunit AcrB, PHOSPHATIDYLETHANOLAMINE | | 著者 | Trinh, T.K.H, Cabezas, A, Catalano, C, Qiu, W, des Georges, A, Guo, Y. | | 登録日 | 2021-08-09 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Multidrug efflux pump subunit AcrB
To Be Published
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1LNW
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5KHN
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2I68
 | | Cryo-EM based theoretical model structure of transmembrane domain of the multidrug-resistance antiporter from E. coli EmrE | | 分子名称: | Protein emrE | | 著者 | Fleishman, S.J, Harrington, S.E, Enosh, A, Halperin, D, Tate, C.G, Ben-Tal, N. | | 登録日 | 2006-08-28 | | 公開日 | 2006-10-03 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (7.5 Å) | | 主引用文献 | Quasi-symmetry in the Cryo-EM Structure of EmrE Provides the Key to Modeling its Transmembrane Domain
J.Mol.Biol., 364, 2006
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5UJA
 | | Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4 | | 分子名称: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1 | | 著者 | Johnson, Z.L, Chen, J. | | 登録日 | 2017-01-17 | | 公開日 | 2017-02-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.
Cell, 168, 2017
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6VKT
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7OJ8
 | | ABCG2 E1S turnover-2 state | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | | 著者 | Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | 登録日 | 2021-05-14 | | 公開日 | 2021-07-21 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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7OJH
 | | ABCG2 topotecan turnover-1 state | | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | | 著者 | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | 登録日 | 2021-05-15 | | 公開日 | 2021-07-21 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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7OJI
 | | ABCG2 topotecan turnover-2 state | | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | | 著者 | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | | 登録日 | 2021-05-16 | | 公開日 | 2021-07-21 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
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1JTY
 | | Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium | | 分子名称: | ETHIDIUM, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-22 | | 公開日 | 2001-12-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JUM
 | | Crystal structure of the multidrug binding transcriptional repressor QacR bound to the natural drug berberine | | 分子名称: | BERBERINE, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-24 | | 公開日 | 2001-12-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JUS
 | | Crystal structure of the multidrug binding transcriptional repressor QacR bound to rhodamine 6G | | 分子名称: | HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, RHODAMINE 6G, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-27 | | 公開日 | 2001-12-12 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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1JT6
 | | Crystal structure of the multidrug binding protein QacR bound to dequalinium | | 分子名称: | DEQUALINIUM, Hypothetical transcriptional regulator IN QACA 5'region, SULFATE ION | | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | | 登録日 | 2001-08-20 | | 公開日 | 2001-12-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
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7SZT
 | | Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in low pH (protonated state) | | 分子名称: | Dodecyldimethylphosphine oxide, L10 monobody, Multidrug resistance protein, ... | | 著者 | Kermani, A.A, Stockbridge, R.B, Burata, O.E. | | 登録日 | 2021-11-29 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates.
Elife, 11, 2022
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5UJ9
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4U8Y
 | | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB | | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Pos, K.M. | | 登録日 | 2014-08-05 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.
Elife, 3, 2014
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4U8V
 | | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB | | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Pos, K.M. | | 登録日 | 2014-08-04 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.298 Å) | | 主引用文献 | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB.
Elife, 3, 2014
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4U95
 | | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB | | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Pos, K.M. | | 登録日 | 2014-08-05 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
eLife, 3, 2014
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4U96
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2J8S
 | | Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors | | 分子名称: | ACRIFLAVINE RESISTANCE PROTEIN B, DARPIN, DODECYL-ALPHA-D-MALTOSIDE, ... | | 著者 | Sennhauser, G, Amstutz, P, Briand, C, Storchenegger, O, Gruetter, M.G. | | 登録日 | 2006-10-27 | | 公開日 | 2007-01-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Drug Export Pathway of Multidrug Exporter Acrb Revealed by Darpin Inhibitors.
Plos Biol., 5, 2007
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