8AF7
 
 | | Room temperature SSX crystal structure of CTX-M-14 (10K dataset) | | 分子名称: | Beta-lactamase, SULFATE ION | | 著者 | Oberthuer, D, Perbandt, M, Prester, A, Rohde, H, Betzel, C, Yefanov, O. | | 登録日 | 2022-07-15 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive.
Iucrj, 9, 2022
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7ZPV
 | | Room temperature SSX crystal structure of CTX-M-14 | | 分子名称: | Beta-lactamase, SULFATE ION | | 著者 | Oberthuer, D, Perbandt, M, Prester, A, Rohde, H, Betzel, C, Yefanov, O. | | 登録日 | 2022-04-29 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive.
Iucrj, 9, 2022
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7Y3Z
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7VQN
 | | Crystal structure of KPC-2 beta-lactamase complexed with hydrolyzed EXW-1 | | 分子名称: | (2R,3S)-3-methyl-4-methylidene-2-[(2S,3R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]-2,3-dihydropyrrole-5-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, SULFATE ION | | 著者 | Xie, H.X. | | 登録日 | 2021-10-20 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Crystal structure of KPC-2 beta-lactamase complexed with hydrolyzed EXW-1
To Be Published
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7V21
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7V1Z
 | | human Serine beta-lactamase-like protein LACTB | | 分子名称: | Serine beta-lactamase-like protein LACTB, mitochondrial | | 著者 | Zhang, M.H, Yang, M.J. | | 登録日 | 2021-08-07 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Structure, 30, 2022
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7V1Y
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7UTB
 | | KPC-2 CARBAPENEMASE IN COMPLEX WITH THE BORONIC ACID INHIBITOR MB_076 | | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, [(1~{R})-1-[2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-2-(4-carboxy-1,2,3-triazol-1-yl)ethyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron | | 著者 | van den Akker, F, Alsenani, T.A. | | 登録日 | 2022-04-26 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M beta-Lactamases: Biochemical and Structural Analyses.
Antimicrob.Agents Chemother., 67, 2023
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7UON
 | | CTX-M-14 Y105W mutant | | 分子名称: | Beta-lactamase, PHOSPHATE ION | | 著者 | Judge, A, Hu, L, Sankaran, B, Van Riper, J, Prasad, B.V.V, Palzkill, T. | | 登録日 | 2022-04-13 | | 公開日 | 2023-01-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M beta-lactamase.
Commun Biol, 6, 2023
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7ULW
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7UL6
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7UDA
 | | Structure of the EstG | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase domain-containing protein, SODIUM ION | | 著者 | Chen, Z, Gabelli, S.B. | | 登録日 | 2022-03-18 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | EstG is a novel esterase required for cell envelope integrity in Caulobacter.
Curr.Biol., 33, 2023
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7UA7
 | | Crystal structure of indoline 9 with KPC-2 | | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, tert-butyl {(3R)-3-[(1H-tetrazol-5-yl)carbamoyl]-1-[3-(trifluoromethyl)benzoyl]-2,3-dihydro-1H-indol-3-yl}carbamate | | 著者 | Akhtar, A, Chen, Y. | | 登録日 | 2022-03-11 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.247 Å) | | 主引用文献 | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors
To Be Published
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7U9B
 | | Crystal structure of indoline 7 with KPC-2 | | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, [(3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-indol-1-yl][3-(trifluoromethyl)phenyl]methanone | | 著者 | Akhtar, A, Chen, Y. | | 登録日 | 2022-03-10 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors
To Be Published
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7U8S
 | | Crystal Structure of KPC-2 with compound 2 | | 分子名称: | 3-fluoro-N-[(1R,3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]benzamide, Carbapenem-hydrolyzing beta-lactamase KPC | | 著者 | Akhtar, A, Chen, Y. | | 登録日 | 2022-03-09 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors
To Be Published
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7U70
 | | Crystal Structure of CTX-M-14 with compound 2 | | 分子名称: | 3-fluoro-N-[(1R,3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]benzamide, Beta-lactamase | | 著者 | Akhtar, A, Chen, Y. | | 登録日 | 2022-03-07 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors
To Be Published
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7U6Q
 | | TEM-1 beta-lactamase | | 分子名称: | Beta-lactamase, SULFATE ION | | 著者 | Ji, Z, Boxer, S.G, Mathews, I.I. | | 登録日 | 2022-03-04 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases.
J.Am.Chem.Soc., 144, 2022
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7U57
 | | apo-CTX-M-15 | | 分子名称: | Beta-lactamase, SULFATE ION | | 著者 | Ahmadvand, P, Kang, C.H. | | 登録日 | 2022-03-01 | | 公開日 | 2022-05-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin.
Int J Mol Sci, 23, 2022
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7U4B
 | | Ampicillin-CTX-M-15 | | 分子名称: | (2S,4S)-2-[(1S)-1-{[(2S)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, SULFATE ION | | 著者 | Ahmadvand, P, Kang, C.H. | | 登録日 | 2022-02-28 | | 公開日 | 2022-05-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin.
Int J Mol Sci, 23, 2022
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7U49
 | | DFC-CTX-M-15 | | 分子名称: | (2R,4S,5R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-oxoethyl]-5-(sulfanylmethyl)-1,3-thiazinane-4-carboxylic acid, Beta-lactamase | | 著者 | Ahmadvand, P, Kang, C.H. | | 登録日 | 2022-02-28 | | 公開日 | 2022-05-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin.
Int J Mol Sci, 23, 2022
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7U48
 | | Clavulanic acid-CTX-M-15 | | 分子名称: | (E)-5-hydroxy-3-oxo-N-(3-oxopropylidene)-L-norvaline, Beta-lactamase, GLYCEROL, ... | | 著者 | Ahmadvand, P, Kang, C.H. | | 登録日 | 2022-02-28 | | 公開日 | 2022-05-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin.
Int J Mol Sci, 23, 2022
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7U1C
 | | Structure of EstG crystalized with SO4 and Tris | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase domain-containing protein, SODIUM ION, ... | | 著者 | Gabelli, S.B, Chen, Z. | | 登録日 | 2022-02-20 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | EstG is a novel esterase required for cell envelope integrity in Caulobacter.
Curr.Biol., 33, 2023
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7U1B
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7TPU
 | | Crystal structure of a chitinase-modifying protein from Fusarium vanettenii (Fvan-cmp) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-lactamase domain-containing protein, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Dowling, N.V, Naumann, T.A, Price, N.P.J, Rose, D.R. | | 登録日 | 2022-01-26 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.194 Å) | | 主引用文献 | Crystal structure of a polyglycine hydrolase determined using a RoseTTAFold model.
Acta Crystallogr D Struct Biol, 79, 2023
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7TI2
 | | Structure of KPC-2 bound to RPX-7063 at 1.75A | | 分子名称: | 1,2-ETHANEDIOL, Carbapenem-hydrolyzing beta-lactamase KPC, {(3R,7S)-2-hydroxy-3-[2-(thiophen-2-yl)acetamido]-2,3,4,7-tetrahydro-1,2-oxaborepin-7-yl}acetic acid | | 著者 | Clifton, M.C, Fairman, J.W, Edwards, T.E, Hecker, S.J. | | 登録日 | 2022-01-12 | | 公開日 | 2022-10-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.
Bioorg.Med.Chem., 62, 2022
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