7TI2

Structure of KPC-2 bound to RPX-7063 at 1.75A

Summary for 7TI2

Entry DOI	10.2210/pdb7ti2/pdb
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, {(3R,7S)-2-hydroxy-3-[2-(thiophen-2-yl)acetamido]-2,3,4,7-tetrahydro-1,2-oxaborepin-7-yl}acetic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	kpc-2, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	29998.48
Authors	Clifton, M.C.,Fairman, J.W.,Edwards, T.E.,Hecker, S.J. (deposition date: 2022-01-12, release date: 2022-10-12, Last modification date: 2023-10-18)
Primary citation	Raja Reddy, K.,Totrov, M.,Lomovskaya, O.,Griffith, D.C.,Tarazi, Z.,Clifton, M.C.,Hecker, S.J. Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability. Bioorg.Med.Chem., 62:116722-116722, 2022 Cited by PubMed: 35358864 DOI: 10.1016/j.bmc.2022.116722 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation