7UTB

KPC-2 CARBAPENEMASE IN COMPLEX WITH THE BORONIC ACID INHIBITOR MB_076

Summary for 7UTB

Entry DOI	10.2210/pdb7utb/pdb
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, [(1~{R})-1-[2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-2-(4-carboxy-1,2,3-triazol-1-yl)ethyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron (3 entities in total)
Functional Keywords	beta-lactamase, carbapenemase, inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	28566.93
Authors	van den Akker, F.,Alsenani, T.A. (deposition date: 2022-04-26, release date: 2022-12-14, Last modification date: 2023-10-25)
Primary citation	Alsenani, T.A.,Rodriguez, M.M.,Ghiglione, B.,Taracila, M.A.,Mojica, M.F.,Rojas, L.J.,Hujer, A.M.,Gutkind, G.,Bethel, C.R.,Rather, P.N.,Introvigne, M.L.,Prati, F.,Caselli, E.,Power, P.,van den Akker, F.,Bonomo, R.A. Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M beta-Lactamases: Biochemical and Structural Analyses. Antimicrob.Agents Chemother., 67:e0093022-e0093022, 2023 Cited by PubMed: 36602311 DOI: 10.1128/aac.00930-22 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.38 Å)

Structure validation