PDB: 267 件ウェブページステータス検索Chemie searchBIRD

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5Y38	Crystal structure of C7orf59-HBXIP complex 分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5, SULFATE ION 著者 Zhang, T, Ding, J. 登録日 2017-07-28 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun, 8, 2017
5Y39	Crystal structure of Ragulator complex (p18 76-145) 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Zhang, T, Ding, J. 登録日 2017-07-28 公開日 2017-12-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1 Nat Commun, 8, 2017
5WKP	Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A 分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... 著者 Boniecki, M.T, Cygler, M. 登録日 2017-07-25 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
5WLW	Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. 分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... 著者 Boniecki, M.T, Cygler, M. 登録日 2017-07-27 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.317 Å) 主引用文献 Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
6B9X	Crystal structure of Ragulator 分子名称: Hepatitis B virus x interacting protein, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 SU, M.-Y, Hurley, J.H. 登録日 2017-10-11 公開日 2017-11-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Mol. Cell, 68, 2017
6EHP	The crystal structure of the human LAMTOR complex 分子名称: CHLORIDE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 Scheffzek, K, Naschberger, A. 登録日 2017-09-14 公開日 2017-10-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. Science, 358, 2017
6EHR	The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Scheffzek, K, Naschberger, A. 登録日 2017-09-14 公開日 2017-10-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.898 Å) 主引用文献 Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. Science, 358, 2017
5OQ4	PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology 分子名称: 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Williams, R.L, Zhang, X. 登録日 2017-08-10 公開日 2017-09-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J. Med. Chem., 60, 2017
5GV2	Crystal structure of Arginine-bound CASTOR1 from Homo sapiens 分子名称: ARGININE, GATS-like protein 3, MAGNESIUM ION 著者 Gai, Z.C, Wu, G. 登録日 2016-09-01 公開日 2017-09-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway Cell Discov, 2, 2016
5GT8	Crystal Structure of apo-CASTOR1 分子名称: GATS-like protein 3 著者 Guo, L, Deng, D. 登録日 2016-08-18 公開日 2017-08-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states Biochem. Biophys. Res. Commun., 508, 2019
5GT7	Crystal Structure of Arg-bound CASTOR1 分子名称: ARGININE, GATS-like protein 3, MALONATE ION 著者 Guo, L, Deng, D. 登録日 2016-08-18 公開日 2017-08-23 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.048 Å) 主引用文献 Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states Biochem. Biophys. Res. Commun., 508, 2019
5NVN	Crystal structure of the human 4EHP-4E-BP1 complex 分子名称: Eukaryotic translation initiation factor 4E type 2, Eukaryotic translation initiation factor 4E-binding protein 1, FORMIC ACID 著者 Peter, D, Sandmeir, F, Valkov, E. 登録日 2017-05-04 公開日 2017-07-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes Dev., 31, 2017
5JXD	Crystal structure of murine Tnfaip8 C165S mutant 分子名称: Tumor necrosis factor alpha-induced protein 8, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate 著者 Park, J, Kim, M.S, Lee, D, Shin, D.H. 登録日 2016-05-13 公開日 2017-06-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.029 Å) 主引用文献 The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin Sci Rep, 7, 2017
5G5J	Crystal structure of human CYP3A4 bound to metformin 分子名称: CYTOCHROME P450 3A4, Metformin, PROTOPORPHYRIN IX CONTAINING FE 著者 Sevrioukova, I. 登録日 2016-05-25 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol, 24, 2017
5NP0	Closed dimer of human ATM (Ataxia telangiectasia mutated) 分子名称: Serine-protein kinase ATM 著者 Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. 登録日 2017-04-13 公開日 2017-05-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
5H64	Cryo-EM structure of mTORC1 分子名称: Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Yang, H, Wang, J, Liu, M, Chen, X, Huang, M, Tan, D, Dong, M, Wong, C.C.L, Wang, J, Xu, Y, Wang, H. 登録日 2016-11-10 公開日 2017-01-25 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1 Protein Cell, 7, 2016
3JBZ	Crystal structure of mTOR docked into EM map of dimeric ATM kinase 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ... 著者 Lau, W.C.Y. 登録日 2015-11-03 公開日 2016-11-16 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (28 Å) 主引用文献 Structure of the human dimeric ATM kinase. Cell Cycle, 15, 2016
5GPG	Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, Serine/threonine-protein kinase mTOR 著者 Lee, H.B, Lee, S.Y, Rhee, H.W, Lee, C.W. 登録日 2016-08-02 公開日 2016-10-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells Acs Cent.Sci., 2, 2016
5T0N	Pseudo-apo structure of Sestrin2 at 3.0 angstrom resolution 分子名称: LEUCINE, Sestrin-2 著者 Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U. 登録日 2016-08-16 公開日 2016-10-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.004 Å) 主引用文献 The apo-structure of the leucine sensor Sestrin2 is still elusive. Sci.Signal., 9, 2016
5D9G	Crystal structure of TIPRL, TOR signaling pathway regulator-like, in complex with peptide 分子名称: CHLORIDE ION, NICKEL (II) ION, PHOSPHATE ION, ... 著者 Scorsato, V, Sandy, J, Brandao-Neto, J, Pereira, H.M, Smetana, J.H.C, Aparicio, R. 登録日 2015-08-18 公開日 2016-08-10 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus. Sci Rep, 6, 2016
5I2C	Arginine-bound CASTOR1 from Homo sapiens 分子名称: ACETATE ION, ARGININE, GATS-like protein 3 著者 Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U. 登録日 2016-02-08 公開日 2016-08-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. Nature, 536, 2016
4ZVV	Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140 分子名称: (2~{R})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Li, Y, Chen, Z, Eigenbrot, C. 登録日 2015-05-18 公開日 2016-05-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat.Chem.Biol., 12, 2016
5FVM	Cryo electron microscopy of a complex of Tor and Lst8 分子名称: SERINE/THREONINE-PROTEIN KINASE TOR2, TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 著者 Baretic, D, Berndt, A, Ohashi, Y, Johnson, C.M, Williams, R.L. 登録日 2016-02-09 公開日 2016-04-20 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Tor Forms a Dimer Through an N-Terminal Helical Solenoid with a Complex Topology Nat.Commun., 7, 2016
5CUF	X-ray crystal structure of SeMet human Sestrin2 分子名称: Sestrin-2 著者 Kim, H, An, S, Ro, S.-H, Lee, J.H, Cho, U.-S. 登録日 2015-07-24 公開日 2016-01-13 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nat Commun, 6, 2015
5FLC	Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction 分子名称: FKBP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, REGULATORY-ASSOCIATED PROTEIN OF MTOR, ... 著者 Aylett, C.H.S, Sauer, E, Imseng, S, Boehringer, D, Hall, M.N, Ban, N, Maier, T. 登録日 2015-10-23 公開日 2015-12-30 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 Architecture of Human Mtor Complex 1 Science, 351, 2016

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