PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

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1TWQ	Crystal structure of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with PGN analog muramyl tripeptide 分子名称: N-acetyl-beta-muramic acid, NICKEL (II) ION, muramyl tripeptide, ... 著者 Guan, R, Roychowdury, A, Boons, G.-A, Mariuzza, R.A. 登録日 2004-07-01 公開日 2004-12-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for peptidoglycan binding by peptidoglycan recognition proteins Proc.Natl.Acad.Sci.USA, 101, 2004
6W0M	Human 8-oxoguanine glycosylase crosslinked with oxoG lesion containing DNA 分子名称: 2-(2-ethoxyethoxy)ethanethiol, DNA (5'-D(P*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), ... 著者 Shigdel, U, Verdine, G. 登録日 2020-03-02 公開日 2020-09-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase. Nat Commun, 11, 2020
6W0R	Human 8-oxoguanine glycosylase interrogating fully intrahelical undamaged DNA 分子名称: 2-(2-ethoxyethoxy)ethanethiol, DNA (5'-D(P*CP*AP*GP*GP*TP*C)-3'), DNA (5'-D(P*CP*CP*TP*GP*G)-3'), ... 著者 Shigdel, U, Verdine, G. 登録日 2020-03-02 公開日 2020-09-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase. Nat Commun, 11, 2020
5LVP	Human PDK1 Kinase Domain in Complex with an HM-Peptide Bound to the PIF-Pocket 分子名称: 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. 登録日 2016-09-14 公開日 2016-10-19 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
5IBD	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 24a 分子名称: 4-(3'-amino[1,1'-biphenyl]-3-yl)-3-(4-methoxyphenyl)-1H-pyrazol-5-amine, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5LXH	GABARAP-L1 ATG4B LIR Complex 分子名称: Cysteine protease ATG4B, GLYCEROL, Gamma-aminobutyric acid receptor-associated protein-like 1, ... 著者 Mouilleron, S, Skytte Rasmussen, M, Kumar Shrestha, B, Wirth, M, Bowitz Larsen, K, Abudu Princely, Y, Sjottem, E, Tooze, S, Lamark, T, Johansen, T, Lee, R. 登録日 2016-09-21 公開日 2017-02-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8. Autophagy, 13, 2017
2ZFX	Crystal structure of the rat vitamin D receptor ligand binding domain complexed with YR301 and a synthetic peptide containing the NR2 box of DRIP 205 分子名称: (2S)-3-{4-[1-ethyl-1-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)propyl]-2-methylphenoxy}propane-1,2-diol, DRIP 205 NR2 box peptide, Vitamin D3 receptor 著者 Kakuda, S, Takimoto-Kamimura, M. 登録日 2008-01-15 公開日 2009-01-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structure of the ligand-binding domain of rat VDR in complex with the nonsecosteroidal vitamin D3 analogue YR301 Acta Crystallogr.,Sect.F, 64, 2008
5LVN	Human PDK1 Kinase Domain in Complex with Adenosine Bound to the ATP-Binding Site 分子名称: 3-phosphoinositide-dependent protein kinase 1, ADENOSINE, CHLORIDE ION, ... 著者 Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. 登録日 2016-09-14 公開日 2016-10-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.379 Å) 主引用文献 Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
6UNM	CYP3A4 bound to an inhibitor 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(naphthalen-1-yl)-3-{[(2S)-3-(naphthalen-1-yl)-1-oxo-1-{(E)-[2-(pyridin-3-yl)ethylidene]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate 著者 Sevrioukova, I. 登録日 2019-10-12 公開日 2020-02-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg.Med.Chem., 28, 2020
3MNP	Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G) mutations at 1.50A 分子名称: DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ... 著者 Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A. 登録日 2010-04-22 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. J.Mol.Biol., 403, 2010
3ME3	Activator-Bound Structure of Human Pyruvate Kinase M2 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, Pyruvate kinase isozymes M1/M2, ... 著者 Hong, B, Dimov, S, Tempel, W, Auld, D, Thomas, C, Boxer, M, Jianq, J.-K, Skoumbourdis, A, Min, S, Southall, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Inglese, J, Park, H, Structural Genomics Consortium (SGC) 登録日 2010-03-31 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat.Chem.Biol., 8, 2012
3MPT	Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor 分子名称: GLYCEROL, Mitogen-activated protein kinase 14, N-(furan-2-ylmethyl)-4-[(2-methylphenyl)carbonyl]-1H-pyrrole-2-carboxamide 著者 Somers, D.O. 登録日 2010-04-27 公開日 2010-07-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38alpha MAP kinase. Bioorg.Med.Chem.Lett., 20, 2010
3MH1	Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-04-07 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Biochemistry, 46, 2007
7ZHS	3D reconstruction of the cylindrical assembly of DnaJA2 delta G/F by imposing D5 symmetry 分子名称: Ubiquitin-like protein SMT3,DnaJ homolog subfamily A member 2, ZINC ION 著者 Cuellar, J, Velasco-Carneros, L, Santiago, C, Martin-Benito, J, Valpuesta, J, Muga, A. 登録日 2022-04-07 公開日 2023-07-26 最終更新日 2024-01-24 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70. Nat Commun, 14, 2023
3MKY	Structure of SopB(155-323)-18mer DNA complex, I23 form 分子名称: DNA (5'-D(*CP*TP*GP*GP*GP*AP*CP*CP*AP*TP*GP*GP*TP*CP*CP*CP*AP*G)-3'), Protein sopB, SULFATE ION 著者 Schumacher, M.A, Piro, K, Xu, W. 登録日 2010-04-15 公開日 2010-05-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes. Nucleic Acids Res., 38, 2010
5LVM	Human PDK1 Kinase Domain in Complex with Adenine Bound to the ATP-Binding Site 分子名称: 3-phosphoinositide-dependent protein kinase 1, ADENINE, DITHIANE DIOL 著者 Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. 登録日 2016-09-14 公開日 2016-10-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
3SEN	Structure of Caskin1 Tandem SAMs 分子名称: Caskin-1, POTASSIUM ION 著者 Stafford, R.L, Bowie, J.U. 登録日 2011-06-10 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure, 19, 2011
5JKW	HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1) COMPLEXED WITH TESTOSTERONE 分子名称: Aromatase, PROTOPORPHYRIN IX CONTAINING FE, TESTOSTERONE 著者 Ghosh, D, Egbuta, C, Lo, J. 登録日 2016-04-26 公開日 2017-04-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Testosterone complex and non-steroidal ligands of human aromatase. J. Steroid Biochem. Mol. Biol., 2018
1K8R	Crystal structure of Ras-Bry2RBD complex 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein kinase byr2, ... 著者 Scheffzek, K, Gruenewald, P, Wohlgemuth, S, Kabsch, W, Tu, H, Wigler, M, Wittinghofer, A, Herrmann, C. 登録日 2001-10-25 公開日 2002-03-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure, 9, 2001
3AUJ	Structure of diol dehydratase complexed with glycerol 分子名称: CALCIUM ION, COBALAMIN, Diol dehydrase alpha subunit, ... 著者 Yamanishi, M, Kinoshita, K, Fukuoka, M, Shibata, T, Tobimatsu, T, Toraya, T. 登録日 2011-02-07 公開日 2012-02-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Redesign of coenzyme B(12) dependent diol dehydratase to be resistant to the mechanism-based inactivation by glycerol and act on longer chain 1,2-diols Febs J., 279, 2012
7ZOX	Nup93 in complex with xhNup93-Nb4i and xNup93-Nb2t 分子名称: Nuclear pore complex protein Nup93, xNup93-Nb2t, xhNup93-Nb4i 著者 Fu, Z, Guttler, T, Colom, M.S. 登録日 2022-04-26 公開日 2023-11-08 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies. Embo J., 2024
3AQK	Structure of bacterial protein (apo form I) 分子名称: Poly(A) polymerase 著者 Toh, Y, Takeshita, D, Tomita , K. 登録日 2010-11-09 公開日 2011-02-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Mechanism for the alteration of the substrate specificities of template-independent RNA polymerases Structure, 19, 2011
1I54	CYTOCHROME C (TUNA) 2FE:1ZN MIXED-METAL PORPHYRINS 分子名称: CYTOCHROME C, HEME C, PROTOPORPHYRIN IX CONTAINING ZN 著者 Crane, B.R, Tezcan, F.A, Winkler, J.R, Gray, H.B. 登録日 2001-02-24 公開日 2001-05-09 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Electron tunneling in protein crystals. Proc.Natl.Acad.Sci.USA, 98, 2001
5MS6	High-salt structure of RavZ LIR2-fused human LC3B 分子名称: Microtubule-associated proteins 1A/1B light chain 3B 著者 Pantoom, S, Vetter, I.R, Wu, Y.W. 登録日 2016-12-31 公開日 2017-04-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins. Elife, 6, 2017
5MTD	Crystal structure of PDF from the Vibrio parahaemolyticus bacteriophage VP16T - crystal form II 分子名称: NICKEL (II) ION, Putative uncharacterized protein orf60T, TRIETHYLENE GLYCOL, ... 著者 Fieulaine, S, Grzela, R, Giglione, C, Meinnel, T. 登録日 2017-01-09 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation. Sci Rep, 7, 2017

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