5LVP

Human PDK1 Kinase Domain in Complex with an HM-Peptide Bound to the PIF-Pocket

Summary for 5LVP

Descriptor3-phosphoinositide-dependent protein kinase 1, hydrophobic-motif peptide of PKB/Akt, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordsprotein kinase, allosteric regulation, small compounds, pif-pocket, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total molecular weight149715.93
Authors
Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Suess, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. (deposition date: 2016-09-14, release date: 2016-10-19, Last modification date: 2019-10-16)
Primary citation
Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Su, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M.
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Cell Chem Biol, 23:1193-1205, 2016
PubMed: 27693059 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2016.06.017
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2244 0.3% 3.5% 1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution