5LVP
Human PDK1 Kinase Domain in Complex with an HM-Peptide Bound to the PIF-Pocket
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 3-phosphoinositide-dependent protein kinase 1 | polymer | 311 | 35392.6 | 4 | UniProt (O15530) Pfam (PF00069) | Homo sapiens (Human) | hPDK1 |
| 2 | E, F, G, H (E, F, G, H) | hydrophobic-motif peptide of PKB/Akt | polymer | 15 | 1511.5 | 4 | Homo sapiens | ||
| 3 | I, J, L, N (A, B, C, D) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 4 | K, M (B, C) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 50 - 359 (UniProt: O15530)
| PDB | External Database | Details |
|---|---|---|
| Gly 49 | - | expression tag |
| Gly 288 | Tyr 288 | engineered mutation |
| Ala 292 | Gln 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 147616.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2099.6 | |
| All* | Total formula weight | 149715.9 |
