6W0M

Human 8-oxoguanine glycosylase crosslinked with oxoG lesion containing DNA

Summary for 6W0M

• Entry DOI: 10.2210/pdb6w0m/pdb
• Descriptor: N-glycosylase/DNA lyase, DNA (5'-D(P*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), ... (6 entities in total)
• Functional Keywords: hogg1, 8-oxog, encounter complex, interrogation complex, dna binding protein, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 44363.66

Authors

Shigdel, U.,Verdine, G. (deposition date: 2020-03-02, release date: 2020-09-23, Last modification date: 2023-10-11)

• Primary citation: Shigdel, U.K.,Ovchinnikov, V.,Lee, S.J.,Shih, J.A.,Karplus, M.,Nam, K.,Verdine, G.L.; The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase.; Nat Commun, 11:4437-4437, 2020; PubMed: 32895378; DOI: 10.1038/s41467-020-18290-2

Experimental method

X-RAY DIFFRACTION (2.37 Å)