6W0M
Human 8-oxoguanine glycosylase crosslinked with oxoG lesion containing DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N-glycosylase/DNA lyase | polymer | 317 | 35586.2 | 1 | UniProt (O15527) Pfam (PF07934) Pfam (PF00730) | Homo sapiens (Human) | |
| 2 | B (B) | DNA (5'-D(P*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*C)-3') | polymer | 13 | 3943.6 | 1 | Homo sapiens | ||
| 3 | C (C) | DNA (5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3') | polymer | 15 | 4635.0 | 1 | Homo sapiens | ||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F (A) | 2-(2-ethoxyethoxy)ethanethiol | non-polymer | 150.2 | 1 | Chemie (S5Y) | |||
| 6 | G, H (A, B) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 12 - 325 (UniProt: O15527)
| PDB | External Database | Details |
|---|---|---|
| Gly 9 | - | expression tag |
| Ser 10 | - | expression tag |
| Glu 11 | - | expression tag |
| Gln 122 | Glu 122 | engineered mutation |
| Cys 207 | Tyr 207 | engineered mutation |
| Gln 249 | Lys 249 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44164.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 198.8 | |
| All* | Total formula weight | 44363.7 |
