3MPT

Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor

Summary for 3MPT

Entry DOI	10.2210/pdb3mpt/pdb
Descriptor	Mitogen-activated protein kinase 14, N-(furan-2-ylmethyl)-4-[(2-methylphenyl)carbonyl]-1H-pyrrole-2-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	p38, serine/threonine protein kinase, map kinase, pyrrole-2-carboxamides, inhibitor, transferase-transferase inhibiator complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	43235.35
Authors	Somers, D.O. (deposition date: 2010-04-27, release date: 2010-07-07, Last modification date: 2023-09-06)
Primary citation	Down, K.,Bamborough, P.,Alder, C.,Campbell, A.,Christopher, J.A.,Gerelle, M.,Ludbrook, S.,Mallett, D.,Mellor, G.,Miller, D.D.,Pearson, R.,Ray, K.,Solanke, Y.,Somers, D. The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38alpha MAP kinase. Bioorg.Med.Chem.Lett., 20:3936-3940, 2010 Cited by PubMed: 20570148 DOI: 10.1016/j.bmcl.2010.05.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation