2JCW
| REDUCED BRIDGE-BROKEN YEAST CU/ZN SUPEROXIDE DISMUTASE ROOM TEMPERATURE (298K) STRUCTURE | 分子名称: | COPPER (I) ION, CU/ZN SUPEROXIDE DISMUTASE, ZINC ION | 著者 | Hart, P.J, Balbirnie, M.M, Ogihara, N.L, Nersissian, A.M, Weiss, M.S, Valentine, J.S, Eisenberg, D. | 登録日 | 1998-12-21 | 公開日 | 1999-06-08 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A structure-based mechanism for copper-zinc superoxide dismutase. Biochemistry, 38, 1999
|
|
2LP0
| |
2LF8
| |
6E8D
| |
2R9Y
| Structure of antiplasmin | 分子名称: | Alpha-2-antiplasmin | 著者 | Law, R.H.P, Sofian, T, Kan, W.T, Horvath, A.J, Hitchen, C.R, Langendorf, C.G, Buckle, A.M, Whisstock, J.C, Coughlin, P.B. | 登録日 | 2007-09-14 | 公開日 | 2007-12-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin Blood, 111, 2008
|
|
7M1X
| |
4W9C
| pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 2) | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(1,3-oxazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Hewitt, S, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
|
|
4W9G
| pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(3-methyl-4-(thiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 6) | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[3-methyl-4-(1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Soares, P, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
|
|
4W9D
| pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methyloxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 3) | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(4-methyl-1,3-oxazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Hewitt, S, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
|
|
3HVT
| STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER | 分子名称: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P51), HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66) | 著者 | Steitz, T.A, Smerdon, S.J, Jaeger, J, Wang, J, Kohlstaedt, L.A, Chirino, A.J, Friedman, J.M, Rice, P.A. | 登録日 | 1994-07-25 | 公開日 | 1994-10-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc.Natl.Acad.Sci.Usa, 91, 1994
|
|
9BOL
| Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5 | 分子名称: | (4R)-1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A. | 登録日 | 2024-05-03 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability To Be Published
|
|
8SCZ
| |
8SD0
| |
6KIW
| Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) | 分子名称: | DNA (144-MER), DNA (145-MER), Histone H2A, ... | 著者 | Huang, J, Xue, H, Yao, T. | 登録日 | 2019-07-20 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
|
|
5DFZ
| Structure of Vps34 complex II from S. cerevisiae. | 分子名称: | Nanobody binding S. cerevisiae Vps34, Phosphatidylinositol 3-kinase VPS34, Putative N-terminal domain of S. cerevisiae Vps30, ... | 著者 | Rostislavleva, K, Soler, N, Ohashi, Y, Zhang, L, Williams, R.L. | 登録日 | 2015-08-27 | 公開日 | 2015-10-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science, 350, 2015
|
|
2YKM
| Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) | 分子名称: | 2-[DIFLUORO-[(4-METHYL-PYRIMIDINYL)-THIO]METHYL]-BENZOXAZOLE, CALCIUM ION, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | 著者 | Boyer, J, Arnoult, E, Medebielle, M, Guillemont, J, Unge, T, Unge, J, Jochmans, D. | 登録日 | 2011-05-28 | 公開日 | 2011-08-17 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. J.Med.Chem., 54, 2011
|
|
7QH3
| |
6QHL
| 14-3-3 sigma with RelA/p65 binding site pS45 | 分子名称: | 14-3-3 protein sigma, GLYCEROL, Transcription factor p65 | 著者 | Wolter, M, Ottmann, C. | 登録日 | 2019-01-16 | 公開日 | 2020-05-13 | 最終更新日 | 2020-12-30 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142, 2020
|
|
6K9L
| 4.27 Angstrom resolution cryo-EM structure of human dimeric ATM kinase | 分子名称: | Serine-protein kinase ATM | 著者 | Xiao, J, Liu, M, Qi, Y, Chaban, Y, Gao, C, Tian, Y, Yu, Z, Li, J, Zhang, P, Xu, Y. | 登録日 | 2019-06-16 | 公開日 | 2019-12-25 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | Structural insights into the activation of ATM kinase. Cell Res., 29, 2019
|
|
7Y1T
| Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Duan, Z, Zhang, Z. | 登録日 | 2022-06-08 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8. Nat Commun, 13, 2022
|
|
7Y1R
| Human L-TGF-beta1 in complex with the anchor protein LRRC33 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Duan, Z, Zhang, Z. | 登録日 | 2022-06-08 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (4.01 Å) | 主引用文献 | Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8. Nat Commun, 13, 2022
|
|
8EBN
| |
4F7M
| Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009 H1N1 PA (649-658) | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | 著者 | Liu, J, Zhang, S, Tan, S, Yi, Y, Wu, B, Zhu, F, Wang, H, Qi, J, George, F.G. | 登録日 | 2012-05-16 | 公開日 | 2012-10-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals. J.Virol., 86, 2012
|
|
6QHM
| 14-3-3 sigma with RelA/p65 binding site pS281 | 分子名称: | 14-3-3 protein sigma, LEU-SEP-GLU | 著者 | Wolter, M, Ottmann, C. | 登録日 | 2019-01-16 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142, 2020
|
|
6QZR
| 14-3-3 sigma in complex with FOXO1 pT24 peptide | 分子名称: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Forkhead box protein O1, ... | 著者 | Ottmann, C, Wolter, M, Lau, R.A. | 登録日 | 2019-03-12 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
|
|