1BXE
 
 | | RIBOSOMAL PROTEIN L22 FROM THERMUS THERMOPHILUS | | Descriptor: | CHLORIDE ION, PROTEIN (RIBOSOMAL PROTEIN L22) | | Authors: | Unge, J, Aberg, A, Al-Karadaghi, S, Nikulin, A, Nikonov, S, Davydova, N, Nevskaya, N, Garber, M, Liljas, A. | | Deposit date: | 1998-10-02 | | Release date: | 1998-10-07 | | Last modified: | 2018-03-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance.
Structure, 6, 1998
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1AD2
 | | RIBOSOMAL PROTEIN L1 MUTANT WITH SERINE 179 REPLACED BY CYSTEINE | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, MERCURY (II) ION, RIBOSOMAL PROTEIN L1, ... | | Authors: | Unge, J, Al-Karadaghi, S, Liljas, A, Jonsson, B.-H, Eliseikina, I, Ossina, N, Nevskaya, N, Fomenkova, N, Garber, M, Nikonov, S. | | Deposit date: | 1997-02-20 | | Release date: | 1997-05-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A mutant form of the ribosomal protein L1 reveals conformational flexibility.
FEBS Lett., 411, 1997
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2UXZ
 | | Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic | | Descriptor: | HIV-1 PROTEASE, METHYL [(1S)-1-({2-[(4R)-4-BENZYL-4-HYDROXY-5-{[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]AMINO}-5-OXOPENTYL]-2-(4-BROMOBENZYL)HYDRAZINO}CARBONYL)-2,2-DIMETHYLPROPYL]CARBAMATE | | Authors: | Ginman, N, Samuelsson, B, Hallberg, A, Unge, J.T, Unge, T.K. | | Deposit date: | 2007-04-02 | | Release date: | 2008-05-20 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic.
J.Med.Chem., 51, 2008
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2UY0
 | | Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary- Alcohol-Containing Transition-State Mimic | | Descriptor: | HIV-1 PROTEASE, METHYL [(1S)-1-({2-[(4R)-4-BENZYL-4-HYDROXY-5-{[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]AMINO}-5-OXOPENTANOYL]-2-(4-BROMOBENZYL)HYDRAZINO}CARBONYL)-2,2-DIMETHYLPROPYL]CARBAMATE | | Authors: | Ginman, N, Samuelsson, B, Hallberg, A, Unge, J.T, Unge, T.K. | | Deposit date: | 2007-04-02 | | Release date: | 2008-05-20 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic.
J.Med.Chem., 51, 2008
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8EUN
 | | MicroED structure of an Aeropyrum pernix protoglobin metallo-carbene complex | | Descriptor: | Protogloblin ApPgb, benzyl[3,3'-(7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~)di(propanoato)(2-)]iron | | Authors: | Danelius, E, Gonen, T, Unge, J.T. | | Deposit date: | 2022-10-19 | | Release date: | 2023-04-05 | | Last modified: | 2023-04-19 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.5 Å) | | Cite: | MicroED Structure of a Protoglobin Reactive Carbene Intermediate.
J.Am.Chem.Soc., 145, 2023
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6HZN
 | | Crystal structure of human dermatan sulfate epimerase 1 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Hasan, M, Unge, J, Westergren-Thorsson, G, Ellervik, U, Mueller, U, Malmstrom, A, Tykesson, E. | | Deposit date: | 2018-10-23 | | Release date: | 2020-01-22 | | Last modified: | 2020-12-16 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
Chem Sci, 2020
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8EUM
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2YKM
 | | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) | | Descriptor: | 2-[DIFLUORO-[(4-METHYL-PYRIMIDINYL)-THIO]METHYL]-BENZOXAZOLE, CALCIUM ION, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | | Authors: | Boyer, J, Arnoult, E, Medebielle, M, Guillemont, J, Unge, T, Unge, J, Jochmans, D. | | Deposit date: | 2011-05-28 | | Release date: | 2011-08-17 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.
J.Med.Chem., 54, 2011
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2YKN
 | | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with a Difluoromethylbenzoxazole (DFMB) Pyrimidine Thioether derivative, a non-nucleoside RT inhibitor (NNRTI) | | Descriptor: | 2-[DIFLUORO-[(4-METHYL-PYRIMIDINYL)-THIO]METHYL]-BENZOXAZOLE, CALCIUM ION, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | | Authors: | Boyer, J, Arnoult, E, Medebielle, M, Guillemont, J, Unge, T, Unge, J, Jochmans, D. | | Deposit date: | 2011-05-28 | | Release date: | 2011-08-17 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.
J.Med.Chem., 54, 2011
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3ZPT
 | | Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors | | Descriptor: | CHLORIDE ION, PROTEASE, methyl N-[(2S)-1-[2-[(4-bromophenyl)methyl]-2-[3-[(3Z,8S,11R)-11-oxidanyl-7,10-bis(oxidanylidene)-8-propan-2-yl-6,9-diazabicyclo[11.2.2]heptadeca-1(16),3,13(17),14-tetraen-11-yl]propyl]hydrazinyl]-3,3-dimethyl-1-oxidanylidene-butan-2-yl]carbamate | | Authors: | Joshi, A, Veron, J.B, Unge, J, Rosenquist, A, Wallberg, H, Samuelsson, B, Hallberg, A, Larhed, M. | | Deposit date: | 2013-03-01 | | Release date: | 2013-11-06 | | Last modified: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
J.Med.Chem., 56, 2013
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7SW3
 | | MicroED structure of proteinase K from a 95 nm thick lamella measured at 200 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.35 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW8
 | | MicroED structure of proteinase K from a 150 nm thick lamella measured at 300 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SVZ
 | | MicroED structure of proteinase K from a 200 nm thick lamella measured at 120 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW4
 | | MicroED structure of proteinase K from a 540 nm thick lamella measured at 200 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.4 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SWA
 | | MicroED structure of proteinase K from a 320 nm thick lamella measured at 300 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SWB
 | | MicroED structure of proteinase K from a 360 nm thick lamella measured at 300 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.05 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW6
 | | MicroED structure of proteinase K from a 260 nm thick lamella measured at 200 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.95 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SVY
 | | MicroED structure of proteinase K from a 130 nm thick lamella measured at 120 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.3 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW2
 | | MicroED structure of proteinase K from a 130 nm thick lamella measured at 200 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.95 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW9
 | | MicroED structure of proteinase K from a 170 nm thick lamella measured at 300 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW1
 | | MicroED structure of proteinase K from a 115 nm thick lamella measured at 200 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.85 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW7
 | | MicroED structure of proteinase K from a 530 nm thick lamella measured at 200 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.3 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW0
 | | MicroED structure of proteinase K from a 325 nm thick lamella measured at 120 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.7 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW5
 | | MicroED structure of proteinase K from a 460 nm thick lamella measured at 200 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.95 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SWC
 | | MicroED structure of proteinase K from a 550 nm thick lamella measured at 300 kV | | Descriptor: | Proteinase K | | Authors: | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | Deposit date: | 2021-11-19 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.9 Å) | | Cite: | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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