3ZPT
Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors
Summary for 3ZPT
Entry DOI | 10.2210/pdb3zpt/pdb |
Related | 3ZPS 3ZPU |
Descriptor | PROTEASE, CHLORIDE ION, methyl N-[(2S)-1-[2-[(4-bromophenyl)methyl]-2-[3-[(3Z,8S,11R)-11-oxidanyl-7,10-bis(oxidanylidene)-8-propan-2-yl-6,9-diazabicyclo[11.2.2]heptadeca-1(16),3,13(17),14-tetraen-11-yl]propyl]hydrazinyl]-3,3-dimethyl-1-oxidanylidene-butan-2-yl]carbamate, ... (4 entities in total) |
Functional Keywords | hydrolase, rational drug design, macrocyclic tertiary alcohol |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22386.39 |
Authors | Joshi, A.,Veron, J.B.,Unge, J.,Rosenquist, A.,Wallberg, H.,Samuelsson, B.,Hallberg, A.,Larhed, M. (deposition date: 2013-03-01, release date: 2013-11-06, Last modification date: 2018-01-17) |
Primary citation | Joshi, A.,Veron, J.B.,Unge, J.,Rosenquist, A.,Wallberg, H.,Samuelsson, B.,Hallberg, A.,Larhed, M. Design and Synthesis of P1-P3 Macrocyclic Tertiary Alcohol Comprising HIV-1 Protease Inhibitors J.Med.Chem., 56:8999-, 2013 Cited by PubMed: 24160253DOI: 10.1021/JM400811D PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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