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6HZN

Crystal structure of human dermatan sulfate epimerase 1

Summary for 6HZN
Entry DOI10.2210/pdb6hzn/pdb
DescriptorDermatan-sulfate epimerase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsepimerase, golgi, glycosaminoglycans, chondroitin sulfate, dermatan sulfate, biosynthetic protein, isomerase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight89484.43
Authors
Hasan, M.,Unge, J.,Westergren-Thorsson, G.,Ellervik, U.,Mueller, U.,Malmstrom, A.,Tykesson, E. (deposition date: 2018-10-23, release date: 2020-01-22, Last modification date: 2024-11-13)
Primary citationHasan, M.,Khakzad, H.,Happonen, L.,Sundin, A.,Unge, J.,Mueller, U.,Malmstrom, J.,Westergren-Thorsson, G.,Malmstrom, L.,Ellervik, U.,Malmstrom, A.,Tykesson, E.
The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
Chem Sci, 2020
Cited by
DOI: 10.1039/D0SC05971D
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.41 Å)
Structure validation

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