6HZN

Crystal structure of human dermatan sulfate epimerase 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dermatan-sulfate epimerase	polymer	761	87261.4	1	UniProt (Q9UL01) Pfam (PF16332) In PDB	Homo sapiens (Human)	DS epimerase,Chondroitin-glucuronate 5-epimerase,Squamous cell carcinoma antigen recognized by T-cells 2,SART-2
2	B	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
3	C	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	A	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN)
6	A	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
7		water	water		18.0	153	Chemie (HOH)

Sequence modifications

A: 23 - 775 (UniProt: Q9UL01)

PDB	External Database	Details
His 776	-	expression tag
His 777	-	expression tag
His 778	-	expression tag
His 779	-	expression tag
His 780	-	expression tag
His 781	-	expression tag
His 782	-	expression tag
His 783	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	87261.4
Branched	Number of molecules	2
	Total formula weight	1335.2
Non-Polymers*	Number of molecules	5
	Total formula weight	887.8
All*	Total formula weight	89484.4

*Water molecules are not included.