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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6HZN

Crystal structure of human dermatan sulfate epimerase 1

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"19004833","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2020","firstPage":"0","lastPage":"0","volume":"11","journal":"Chem. Sci.","title":"The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.","authors":["Hasan M.","Khakzad H.","Happonen L.","Sundin A.","Unge J.","Mueller U.","Malmstrom J.","Westergren-Thorsson G.","Malmstrom L.","Ellervik U.","Malmstrom A.","Tykesson E."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/D0SC05971D"}]}}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PubMed","id":"19004833","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2020","firstPage":"0","lastPage":"0","volume":"11","journal":"Chem. Sci.","title":"The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.","authors":["Hasan M.","Khakzad H.","Happonen L.","Sundin A.","Unge J.","Mueller U.","Malmstrom J.","Westergren-Thorsson G.","Malmstrom L.","Ellervik U.","Malmstrom A.","Tykesson E."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/D0SC05971D"}]}}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2020","firstPage":"0","lastPage":"0","volume":"11","journal":"Chem. Sci.","title":"The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.","authors":["Hasan M.","Khakzad H.","Happonen L.","Sundin A.","Unge J.","Mueller U.","Malmstrom J.","Westergren-Thorsson G.","Malmstrom L.","Ellervik U.","Malmstrom A.","Tykesson E."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/D0SC05971D"}]}},{"source":"PDB","id":"6HZN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsSite: {"description":"Critical for catalysis","evidences":[{"source":"PubMed","id":"19004833","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19004833","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2020","firstPage":"0","lastPage":"0","volume":"11","journal":"Chem. Sci.","title":"The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.","authors":["Hasan M.","Khakzad H.","Happonen L.","Sundin A.","Unge J.","Mueller U.","Malmstrom J.","Westergren-Thorsson G.","Malmstrom L.","Ellervik U.","Malmstrom A.","Tykesson E."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/D0SC05971D"}]}},{"source":"PDB","id":"6HZN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine","evidences":[{"source":"PubMed","id":"19004833","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2020","firstPage":"0","lastPage":"0","volume":"11","journal":"Chem. Sci.","title":"The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.","authors":["Hasan M.","Khakzad H.","Happonen L.","Sundin A.","Unge J.","Mueller U.","Malmstrom J.","Westergren-Thorsson G.","Malmstrom L.","Ellervik U.","Malmstrom A.","Tykesson E."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/D0SC05971D"}]}},{"source":"PDB","id":"6HZN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2020","firstPage":"0","lastPage":"0","volume":"11","journal":"Chem. Sci.","title":"The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.","authors":["Hasan M.","Khakzad H.","Happonen L.","Sundin A.","Unge J.","Mueller U.","Malmstrom J.","Westergren-Thorsson G.","Malmstrom L.","Ellervik U.","Malmstrom A.","Tykesson E."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/D0SC05971D"}]}},{"source":"PDB","id":"6HZN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (paucimannose) asparagine","evidences":[{"source":"PubMed","id":"19004833","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2020","firstPage":"0","lastPage":"0","volume":"11","journal":"Chem. Sci.","title":"The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.","authors":["Hasan M.","Khakzad H.","Happonen L.","Sundin A.","Unge J.","Mueller U.","Malmstrom J.","Westergren-Thorsson G.","Malmstrom L.","Ellervik U.","Malmstrom A.","Tykesson E."],"citationCrossReferences":[{"database":"DOI","id":"10.1039/D0SC05971D"}]}},{"source":"PDB","id":"6HZN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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