PDB: 1414 件ウェブページステータス検索Chemie searchBIRD

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8JBA	Discovery and Crystallography Study of Novel Oxadiazole Analogs as Small Molecule PD-1/PD-L1 inhibitors 分子名称: (2~{S})-2-[[3-[[5-[(2-methyl-3-phenyl-phenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]methylamino]-3-oxidanyl-propanoic acid, Programmed cell death 1 ligand 1 著者 Cheng, Y, Xiao, Y.B. 登録日 2023-05-08 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J.Med.Chem., 66, 2023
8JBV	Extracellular domain of gamma delta TCR 分子名称: T cell receptor delta variable 1,T cell receptor delta constant, T cell receptor gamma variable 5,T cell receptor gamma constant 1 著者 Xin, W, Chi, X, Huang, B, Su, Q, Zhou, Q. 登録日 2023-05-09 公開日 2024-05-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
8JC0	V gamma9 V delta2 TCR and CD3 complex in LMNG 分子名称: CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... 著者 Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-05-10 公開日 2024-05-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
8JCB	Vgamma5 Vdelta1 T cell receptor complex 分子名称: T cell receptor delta variable 1,T cell receptor delta constant, T cell receptor gamma variable 5,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... 著者 Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. 登録日 2023-05-10 公開日 2024-05-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (9.5 Å) 主引用文献 Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
8P1O	Solubilizer tag effect on PD-L1/inhibitor binding properties for m-terphenyl derivatives 分子名称: (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, Programmed cell death 1 ligand 1, ... 著者 Plewka, J, Magiera-Mularz, K, Surmiak, E, Kalinowska-Tluscik, J, Holak, T.A. 登録日 2023-05-12 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives. Acs Med.Chem.Lett., 15, 2024
8SVE	Structure of Monomeric Interleukin-10 Grafted into and Antibody CDR 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Fab Heavy chain, ... 著者 DiDonato, M, Spraggon, G. 登録日 2023-05-16 公開日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A Novel Interleukin-10 Antibody Graft to Treat Inflammatory Bowel Disease. To Be Published
8JEL	Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I 分子名称: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain 著者 Sun, J, Zhang, X.X, Song, J. 登録日 2023-05-16 公開日 2024-02-28 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
8JEN	Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II 分子名称: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain 著者 Sun, J, Zhang, X.X, Song, J. 登録日 2023-05-16 公開日 2024-02-28 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
8JEO	Crystal structure of TIGIT in complexed with Tiragolumab 分子名称: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain 著者 Sun, J, Zhang, X.X, Song, J. 登録日 2023-05-16 公開日 2024-02-28 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
8P64	Co-crystal structure of PD-L1 with low molecular weight inhibitor 分子名称: Programmed cell death 1 ligand 1, ~{N}-[[1-[(~{E})-2-(2-methyl-3-phenyl-phenyl)ethenyl]-1,2,3,4-tetrazol-5-yl]methyl]ethanamine 著者 Plewka, J, Magiera-Mularz, K, van der Straat, R, Draijer, R, Surmiak, E, Butera, R, Land, L, Musielak, B, Domling, A. 登録日 2023-05-25 公開日 2024-03-06 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.312 Å) 主引用文献 1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists. Rsc Med Chem, 15, 2024
8SZY	Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BMS-986207 Fab Heavy Chain, BMS-986207 light chain, ... 著者 Diong, S.J, Lee, P.S. 登録日 2023-05-30 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT. Mabs, 15, 2023
8T4Z	T-cell receptor and lipid complex structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, Beta-2-microglobulin, ... 著者 Praveena, T, Rossjohn, J. 登録日 2023-06-12 公開日 2024-08-07 最終更新日 2024-09-04 実験手法 X-RAY DIFFRACTION (2.691 Å) 主引用文献 Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells. Proc.Natl.Acad.Sci.USA, 121, 2024
8TBB	F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, F9S Fab heavy chain, F9S Fab light chain, ... 著者 Oganesyan, V, van Dyk, N, Mazor, Y, Yang, C. 登録日 2023-06-28 公開日 2024-08-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3 To be published
8TBQ	The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, SNS-101 Fab heavy chain, ... 著者 van der Horst, E.H, Mukherjee, A, Thisted, T. 登録日 2023-06-29 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.593 Å) 主引用文献 The pH-selective anti-VISTA antibody SNS-101 displays a favorable pharmacokinetic and safety profile and promotes anti-tumoral M1 macrophage polarization in PD-1 refractory settings To Be Published
8TE6	Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain 分子名称: V-set and immunoglobulin domain-containing protein 4 著者 Abram, T.G, Geisbrecht, B.V. 登録日 2023-07-05 公開日 2023-07-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.251 Å) 主引用文献 New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023
8TE5	Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain 分子名称: V-set and immunoglobulin domain-containing protein 4 著者 Abram, T.G, Geisbrecht, B.V. 登録日 2023-07-05 公開日 2023-07-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.502 Å) 主引用文献 New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023
8TFT	Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, O-13-1 IgG1 Fab heavy chain, O-13-1 IgG1 Fab light chain, ... 著者 Oganesyan, V.Y, van Dyk, N, Mazor, Y, Yang, C. 登録日 2023-07-11 公開日 2024-08-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3 To be published
8THH	Cryo-EM structure of Nav1.7 with LTG 分子名称: (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... 著者 Fan, X, Huang, J, Yan, N. 登録日 2023-07-16 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8THG	Cryo-EM structure of Nav1.7 with RLZ 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Fan, X, Huang, J, Yan, N. 登録日 2023-07-16 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8K5N	Discovery of Novel PD-L1 Inhibitors That Induce Dimerization and Degradation of PD-L1 Based on Fragment Coupling Strategy 分子名称: 3-[(1~{S})-1-[6-methoxy-3-methyl-5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyridin-2-yl]oxy-2,3-dihydro-1~{H}-inden-4-yl]-2-methyl-~{N}-[5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyridin-2-yl]benzamide, Programmed cell death 1 ligand 1 著者 Cheng, Y, Xiao, Y.B. 登録日 2023-07-22 公開日 2024-01-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy. J.Med.Chem., 66, 2023
8TQK	Human parainfluenza virus type 3 prefusion F trimer in complex with rPIV3-18 Fab 分子名称: Fusion glycoprotein F0, Heavy chain Fab rPIV3-18, Light chain Fab rPIV3-28 著者 Otrelo-Cardoso, A.R, Jardetzky, T.S. 登録日 2023-08-07 公開日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Functional and structural characteristics of human monoclonal antibodies that potently neutralize human parainfluenza virus type 3 To be published
8QH1	Crystal structure of the SARS-CoV-2 RBD from the Omicron BA4 variant with the antibody Cv2.3194 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cv2.3194 heavy chain, IGK@ protein, ... 著者 Fernandez, I, Rey, F.A. 登録日 2023-09-06 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Pan-neutralizing antibody isolated from a COVID patient To Be Published
8QH0	Crystal structure of the SARS-CoV-2 RBD with the antibody Cv2.3194 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cv2.3194 Heavy chain, GLYCEROL, ... 著者 Fernandez, I, Rey, F.A. 登録日 2023-09-06 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 A broadly neutralizing antibody against SARS-CoV-2 Omicron variants To Be Published
8U32	Crystal structure of PD-1 in complex with a Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... 著者 Sun, D, Masureel, M. 登録日 2023-09-07 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
8U31	Crystal structure of PD-1 in complex with a Fab 分子名称: Fab heavy chain, Fab light chain, GLYCEROL, ... 著者 Sun, D, Masureel, M. 登録日 2023-09-07 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024

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