8TBQ

The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody

Summary for 8TBQ

• Entry DOI: 10.2210/pdb8tbq/pdb
• Descriptor: SNS-101 Fab heavy chain, SNS-101 Fab light chain, V-type immunoglobulin domain-containing suppressor of T-cell activation, ... (6 entities in total)
• Functional Keywords: vista, ph-selective, sns-101, pd-1, protein binding, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 132211.84

Authors

van der Horst, E.H.,Mukherjee, A.,Thisted, T. (deposition date: 2023-06-29, release date: 2024-03-20)

• Primary citation: Thisted, T.,Smith, F.D.,Zhang, G.,Feng, F.,Kleschenko, Y.,Mukherjee, A.,Jiang, Z.,Malhotra, K.,Biesova, Z.,Onumajuru, A.,Gaelle, M.,Takeuchi, Y.,Thiam, K.,Schreiber, R.D.,van der Horst, E.H.; The pH-selective anti-VISTA antibody SNS-101 displays a favorable pharmacokinetic and safety profile and promotes anti-tumoral M1 macrophage polarization in PD-1 refractory settings; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.593 Å)