8TBQ
The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (H, A) | SNS-101 Fab heavy chain | polymer | 229 | 24336.1 | 2 | Homo sapiens | ||
| 2 | B, E (L, B) | SNS-101 Fab light chain | polymer | 215 | 23414.9 | 2 | Homo sapiens | ||
| 3 | C, F (P, Q) | V-type immunoglobulin domain-containing suppressor of T-cell activation | polymer | 159 | 17961.1 | 2 | UniProt (Q9H7M9) Pfam (PF07686) | Homo sapiens (human) | |
| 4 | G, H (H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | I, J, K (P, Q) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 6 | L, M, N, O, P... (H, L, P, A, B...) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
P, Q: 33 - 191 (UniProt: Q9H7M9)
| PDB | External Database | Details |
|---|---|---|
| Gln 91 | Asn 91 | conflict |
| Gln 108 | Asn 108 | conflict |
| Gln 190 | Asn 190 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 131424.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 787.8 | |
| All* | Total formula weight | 132211.8 |
