8SVE

Structure of Monomeric Interleukin-10 Grafted into and Antibody CDR

Summary for 8SVE

• Entry DOI: 10.2210/pdb8sve/pdb
• Descriptor: Fab Heavy chain, Interleukin-10,Fab light chain, ACETATE ION, ... (5 entities in total)
• Functional Keywords: antibody cytokine graft, engineered protein, immune regulatory cytokine, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 133413.33

Authors

DiDonato, M.,Spraggon, G. (deposition date: 2023-05-16, release date: 2024-05-22)

• Primary citation: DiDonato, M.,Spraggon, G.,Simpson, C.T.,Vo, M.T.,Knuth, M.,Geierstanger, B.,Jamontt, J.,Fathman, J.J.,DeLarosa, D.,Junt, T.,Picard, D.,Sommer, U.,Vogel, B.,Bagger, M.,Peters, E.,Meeusen, S.; A Novel Interleukin-10 Antibody Graft to Treat Inflammatory Bowel Disease.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)