8SVE
Structure of Monomeric Interleukin-10 Grafted into and Antibody CDR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H, I | Fab Heavy chain | polymer | 227 | 24349.4 | 2 | Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (P0DOX5) In PDB | Homo sapiens (human) | |
2 | L, M | Interleukin-10,Fab light chain | polymer | 379 | 42172.5 | 2 | UniProt (P22301) Pfam (PF00726) In PDB | Homo sapiens (human) | IL-10,Cytokine synthesis inhibitory factor,CSIF |
3 | H | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
4 | I, L, M | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
5 | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence modifications
L, M: 29 - 194 (UniProt: P22301)
L, M: 195 - 379 (PDB: 8SVE)
PDB | External Database | Details |
---|---|---|
Asp 1 | - | expression tag |
Ile 2 | - | expression tag |
Gln 3 | - | expression tag |
Met 4 | - | expression tag |
Thr 5 | - | expression tag |
Gln 6 | - | expression tag |
Ser 7 | - | expression tag |
Pro 8 | - | expression tag |
Ser 9 | - | expression tag |
Thr 10 | - | expression tag |
Leu 11 | - | expression tag |
Ser 12 | - | expression tag |
Ala 13 | - | expression tag |
Ser 14 | - | expression tag |
Val 15 | - | expression tag |
Gly 16 | - | expression tag |
Asp 17 | - | expression tag |
Arg 18 | - | expression tag |
Val 19 | - | expression tag |
Thr 20 | - | expression tag |
Ile 21 | - | expression tag |
Thr 22 | - | expression tag |
Cys 23 | - | expression tag |
Lys 24 | - | expression tag |
Ala 25 | - | expression tag |
Gln 26 | - | expression tag |
Leu 27 | - | expression tag |
Ser 28 | - | expression tag |
Gly 145 | - | insertion |
Gly 146 | - | insertion |
Gly 147 | - | insertion |
Ser 148 | - | insertion |
Gly 149 | - | insertion |
Gly 150 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 133043.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 369.4 | |
All* | Total formula weight | 133413.3 |