8TBB
F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3
Summary for 8TBB
Entry DOI | 10.2210/pdb8tbb/pdb |
Descriptor | T-cell immunoglobulin mucin receptor 3, F9S Fab heavy chain, F9S Fab light chain, ... (5 entities in total) |
Functional Keywords | fab, igv domain of tim-3, complex, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 60055.29 |
Authors | Oganesyan, V.,van Dyk, N.,Mazor, Y.,Yang, C. (deposition date: 2023-06-28, release date: 2024-08-28) |
Primary citation | Clancy-Thompson, E.,Perry, T.,Pryts, S.,Jaiswal, A.,Oganesyan, V.,van Dyk, N.,Yang, C.,Garcia, A.,Yu, W.,Moynihan, J.,Miller, C.,Mulgrew, K.,Cobbold, M.,Mazor, Y.,Hammond, S.,Pollizzi, K. Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3 To be published, |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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